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Use of low-level laser therapy (LLLT) or photobiomodulation (PBM) for the management of the hand-foot syndrome (HSF) or palmo-plantar erythrodysesthesia (PPED) associated with cancer therapy

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Abstract

The purpose of this pilot study was to determine whether photobiomodulation (PBM) might be effective for chemotherapy-induced palmo-plantar erythrodyesthesia (PPED), as it is for mucositis or radio dermatitis; no standard therapy exists for PPED. Patients were allocated to PBM or sham irradiation and were blindly assessed after 2 weeks. Pain and satisfaction with treatment were also evaluated. We found a significant benefit from PBM in comparison with sham treatment (p < 0.03) and a decrease of pain in 49% of the patients. No adverse reactions were observed. We concluded that PBM might represent a useful approach for the management of PPED.

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Acknowledgments

The authors thank M. Paesmans (Data Center Institut Jules Bordet) for advising about the sample size and analyzing the results and MA Echterbille for dedicated editorial assistance.

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Authors and Affiliations

  1. Medical Oncology Department, Institut Jules Bordet, Université Libre de Bruxelles Centre des Tumeurs de l’ULB, Rue Héger-Bordet, 1, 1000, Brussels, Belgium

    S. Latifyan, B. Fernez & J. A. Klastersky

  2. Laser Therapy Unit, Institut Jules Bordet, Université Libre de Bruxelles Centre des Tumeurs de l’ULB, Rue Héger-Bordet, 1, 1000, Brussels, Belgium

    M.T. Genot & M.F. Scharll

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  1. S. Latifyan
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  2. M.T. Genot
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  3. B. Fernez
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  4. M.F. Scharll
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  5. J. A. Klastersky
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by MT Genot, S. Latifyan, B. Fernez, and MF Scharll. The first draft of the manuscript was written by JA Klastersky and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to J. A. Klastersky.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee Comité d’Ethique de l’Institut Jules Bordet – ref 101) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Latifyan, S., Genot, M., Fernez, B. et al. Use of low-level laser therapy (LLLT) or photobiomodulation (PBM) for the management of the hand-foot syndrome (HSF) or palmo-plantar erythrodysesthesia (PPED) associated with cancer therapy. Support Care Cancer 28, 3287–3290 (2020). https://doi.org/10.1007/s00520-019-05099-z

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  • DOI: https://doi.org/10.1007/s00520-019-05099-z

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