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The effectiveness and safety of same-day versus next-day administration of long-acting granulocyte colony-stimulating factors for the prophylaxis of chemotherapy-induced neutropenia: a systematic review

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Abstract

Purpose

Granulocyte colony-stimulating factors (G-CSF) are commonly used in clinical practice to prevent febrile neutropenia (FN). US and EU prescribing information and treatment guidelines from the NCCN, ASCO, and EORTC specify that pegfilgrastim, a long-acting (LA) G-CSF, should be administered at least 24 h after myelosuppressive chemotherapy. Nevertheless, many patients receive LA G-CSFs on the same day as chemotherapy. This systematic literature review evaluated the relative merits of same-day versus next-day dosing of LA G-CSFs.

Methods

A broad Ovid MEDLINE® and Embase® literature search was conducted that examined all publications indexed before May 9, 2016 that compared same-day versus next-day LA G-CSF administration. A congress abstract literature search included congresses from January 1, 2011 to April 6, 2016. The parameters for this review were prospectively delineated in a research protocol and adhered to the PRISMA Guidelines.

Results

The first part of the systematic literature search identified 1736 publications. After elimination of duplicates, title/abstract screening was conducted on 1440 records, and full text review was conducted on 449 publications. Eleven publications met all criteria and are included in this systematic review; of these, four included data from randomized or single arm prospective studies, and seven were retrospective studies. In most studies included in this review and across a variety of tumor types, administration of pegfilgrastim at least 24 h after myelosuppressive chemotherapy resulted in improved patient outcomes.

Conclusions

Data from multiple publications support administration of pegfilgrastim at least 1 day after chemotherapy.

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Acknowledgement

The authors thank James Ziobro (funded by Amgen Inc.), and Micah Robinson (Amgen Inc.) for providing medical writing support. This study was funded by Amgen Inc.

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Authors and Affiliations

  1. Fred Hutchinson Cancer Research Center and University of Washington, 1100 Fairview Avenue North, Seattle, WA, 98109, USA

    Gary H. Lyman

  2. Oxford PharmaGenesis Ltd., Oxford, UK

    Kim Allcott

  3. Amgen Inc., Thousand Oaks, CA, USA

    Jacob Garcia, Scott Stryker, Yanli Li & Maureen T. Reiner

  4. Policy Analysis Inc. (PAI), Brookline, MA, USA

    Derek Weycker

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  1. Gary H. Lyman
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  5. Yanli Li
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Corresponding author

Correspondence to Gary H. Lyman.

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Conflict of interest

Gary H Lyman is the principal investigator on a research grant to Fred Hutchinson Cancer Research Center from Amgen Inc. Kim Allcott is an employee of Oxford PharmaGenesis Ltd., and Oxford PharmaGenesis Ltd. has received research funding from Amgen Inc. Jacob Garcia is a former employee of Amgen Inc., is a stockholder in Amgen Inc., and is currently an employee of and stockholder in Juno Therapeutics Inc. Scott Stryker is an employee of and stockholder in Amgen Inc. Yanli Li is an employee of and stockholder in Amgen Inc. Maureen T Reiner is an employee of and stockholder in Amgen Inc. Derek Weycker is an employee of Policy Analysis Inc., and Policy Analysis Inc. has received research funding from Amgen Inc.

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Lyman, G.H., Allcott, K., Garcia, J. et al. The effectiveness and safety of same-day versus next-day administration of long-acting granulocyte colony-stimulating factors for the prophylaxis of chemotherapy-induced neutropenia: a systematic review. Support Care Cancer 25, 2619–2629 (2017). https://doi.org/10.1007/s00520-017-3703-y

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  • DOI: https://doi.org/10.1007/s00520-017-3703-y

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