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Complex management of resistant oral herpes simplex virus infection following hematopoietic stem cell transplantation: potential role of topical cidofovir

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Supportive Care in Cancer Aims and scope Submit manuscript

An Erratum to this article was published on 08 June 2016

Abstract

Purpose

Herpes simplex virus (HSV) infection commonly occurs during the immunosuppression associated with hematopoietic stem cell transplantation (HSCT). Prophylaxis of recurrent infection and management of clinical infection have relied upon acyclovir and congeners. More recently, resistant HSV infection is seen in HSCT and presents new challenges in management. We present a case of HSV following HSCT that provided effective symptomatic management.

Results

Oral symptoms and lesions were repeatedly reduced when topical cidofovir was used, strongly supporting the effect of cidofovir used in a host who could not tolerate systemic antiviral medications.

Conclusions

Topical cidofovir can provide effective management of symptomatic oropharyngeal HSV while reducing risk of systemic toxicity and drug interaction and represents an additional approach to management for management in medically compromised patients.

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Authors and Affiliations

  1. Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Joel B. Epstein & Michael Lill

  2. Cedars-Sinai Health System, Los Angeles, CA, USA

    Joel B. Epstein, Sara Gharapetian, Ali R. Rejali, Rachel Zabner & Michael Lill

  3. Blood and Marrow Transplant Program, University of California, San Diego, San Diego, CA, USA

    Michael Lill & Dimitrios Tzachanis

Authors
  1. Joel B. Epstein
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  2. Sara Gharapetian
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  3. Ali R. Rejali
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  4. Rachel Zabner
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  5. Michael Lill
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  6. Dimitrios Tzachanis
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Correspondence to Joel B. Epstein.

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Epstein, J.B., Gharapetian, S., Rejali, A.R. et al. Complex management of resistant oral herpes simplex virus infection following hematopoietic stem cell transplantation: potential role of topical cidofovir. Support Care Cancer 24, 3603–3606 (2016). https://doi.org/10.1007/s00520-016-3264-5

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  • DOI: https://doi.org/10.1007/s00520-016-3264-5

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