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Comparison between exercise therapy and non-hydrolyzed collagen (UC-II) in functionality and quality of life in women with knee osteoarthritis

A randomized controlled clinical trial

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Summary

Background

Knee osteoarthritis (OA) is characterized by a progressive degeneration of cartilage and menisci, leading to pain and locomotor disability. Here, we aimed to assess the effect of an exercise protocol and the oral use of non-hydrolyzed collagen (UC-II) on the functionality and quality of life of women with knee OA.

Material and methods

Individuals were divided into three groups (CG [control group]; MG [medication group]; EG [exercise group]). In the CG there was no intervention, while MG received an oral dose (1 capsule/day) of UC-II and the EG held 12 sessions of an exercise protocol.

Results

In the functionality tests (6-min walk test, 6MWT and timed up and go test [TUG]) the EG (p < 0.001/p = 0.020) and MG (p = 0.010/p = 0.010) revealed a significant improvement when compared to the CG. In the analysis of quality of life by WOMAC, a significant improvement was found only in the EG (p = 0.030) when compared to the CG; the same happened in the stiffness domain (EG, p = 0.010), despite in the pain domain, both the EG (p < 0.001) and the MG (p = 0.060) were better than the CG.

Conclusion

Data obtained here reveal that an exercise protocol and UC-II have similar effects for functionality, despite exercise being superior in promoting the quality of life score.

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Acknowledgements

The authors were supported by grants from FAPITEC-SE, CAPES and CNPq (all from Brazil). SM and ES were receiving scholarships from the Graduate Program in Health Sciences/UFS. NM acknowledges the Portuguese Foundation for Science and Technology under the Horizon 2020 Program (PTDC/PSI-GER/28076/2017).

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Authors and Affiliations

  1. Federal University of Sergipe, UFS, Aracaju, Brazil

    Érika Thatyana Nascimento Santana, Viviane Nascimento Brandão Lima, Valter Joviniano DeSantana Filho, Leonardo Yung dos Santos Maciel, Jader Pereira de Farias Neto, Walderi Monteiro da Silva Júnior & Lucindo J. Quintans Júnior

  2. Regional University of Cariri, URCA, Crato, Brazil

    Saulo da Cunha Machado & Henrique Douglas Melo Coutinho

  3. Faculty of Medicine, University of Porto, Porto, Portugal

    Natália Martins

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  1. Érika Thatyana Nascimento Santana
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Contributions

S.M., V.B. and E.S. designed the study, analyzed the data and wrote the manuscript. L.M., W.M.Jr. and J.d.F.N. contributed to the design of the methodology. L.J.Q.Jr. and V.J.d.S.F. contributed to the writing of the manuscript and statistical analysis of data and figures; H.D.M.C. and N.M. coordinated the project. All authors have read and agreed to the published version of the manuscript.

Corresponding author

Correspondence to Henrique Douglas Melo Coutinho.

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Conflict of interest

É.T.N. Santana, S. da Cunha Machado, V.N. Brandão Lima, V.J. DeSantana Filho, L.Y. dos Santos Maciel, J.P. de Farias Neto, H.D.M. Coutinho, N. Martins, W. Monteiro da Silva Júnior and L.J. Quintans Júnior declare that they have no competing interests.

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For this article no studies with human participants or animals were performed by any of the authors. All studies mentioned were in accordance with the ethical standards indicated in each case.

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Santana, É.T.N., da Cunha Machado, S., Brandão Lima, V.N. et al. Comparison between exercise therapy and non-hydrolyzed collagen (UC-II) in functionality and quality of life in women with knee osteoarthritis. Wien Klin Wochenschr 135, 291–300 (2023). https://doi.org/10.1007/s00508-022-02037-8

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