Abstract
Diabetic retinopathy (DR) is one among the common disease associated with the human eye that can cause blindness. Detection of DR is very important as the disease will damage the eye with the passage of time. A computer-aided diagnosis-based system is used nowadays to assist the medical practitioner to correctly detect DR during the early stages. In this work, a retinal image’s classification is proposed, which is composed of three major blocks. Initially, the images are preprocessed using CLAHE and DNCNN neural networks, which will reduce the induced noise in the images. Preprocessed images then segmented using morphological and K-mean algorithms. The enhanced images have shown a better peak signal-to-noise ratio. The segmented images are then fed to the proposed EyeNet, which is a transfer learning-based model. The architecture of EyeNet is based on ResNet-18. The network is trained on more than 1500 images from clinical, DRIVE, and STARE databases and has shown an accuracy of 99.76%.
Similar content being viewed by others
References
Abdelsalam MM (2020) Effective blood vessels reconstruction methodology for early detection and classification of diabetic retinopathy using OCTA images by artificial neural network. Inform Med Unlocked 20:100390. https://doi.org/10.1016/j.imu.2020.100390
Abràmoff MD, Lou Y, Erginay A, Clarida W, Amelon R, Folk JC, Niemeijer M (2016) Improved automated detection of diabetic retinopathy on a publicly available dataset through integration of deep learning. Invest Ophthalmol vis Sci 57(13):5200–5206. https://doi.org/10.1167/iovs.16-19964
Acharya UR, Hagiwara Y, Koh JEW, Tan JH, Bhandary SV, Rao AK, Raghavendra U (2017) Automated screening tool for dry and wet age-related macular degeneration (ARMD) using pyramid of histogram of oriented gradients (PHOG) and nonlinear features. J Comput Sci 20:41–51. https://doi.org/10.1016/j.jocs.2017.03.005
Agarwal R, Mahamuni A, Gautam N, Awachar P, Sagar P (2019) Detection of diabetic retinopathy using convolutional neural network. Int J Recent Technol Eng 8(4):1957–1960. https://doi.org/10.35940/ijrte.c6303.118419
Al Hazaimeh OM, Nahar KMO, Al Naami B, Gharaibeh N (2018) An effective image processing method for detection of diabetic retinopathy diseases from retinal fundus images. Int J Sign Imag Syst Eng 11(4):206. https://doi.org/10.1504/ijsise.2018.10015063
Alyoubi WL, Shalash WM, Abulkhair MF (2020) Diabetic retinopathy detection through deep learning techniques: a review. Inform Med Unlocked 20(June):100377. https://doi.org/10.1016/j.imu.2020.100377
Amanda I, Zakaria H (2019) Development of diabetic retinopathy early detection and its implementation in Android application. AIP Conference Proceedings, 2193(December). https://doi.org/10.1063/1.5139396
Amin J, Sharif M, Yasmin M, Ali H, Fernandes SL (2017) A method for the detection and classification of diabetic retinopathy using structural predictors of bright lesions. J Comput Sci 19:153–164. https://doi.org/10.1016/j.jocs.2017.01.002
Bhupati A (2020) Transfer learning for detection of diabetic retinopathy disease research project MSc Data analytics Alekhya Bhupati Student ID : x18132634 School of Computing National College of Ireland Supervisor: Dr. Catherine Mulwa, (May). https://doi.org/10.13140/RG.2.2.24009.57441
Carrijo GA, de Fatima dos Santos Cardoso C, Ferreira JC, Sousa PM, Patrocínio AC (2020) Image enhancement for blood vessel detection via a neural network using CLAHE and Wiener filter. IEEE Res Biomed Eng 36(2):107–119. https://doi.org/10.1007/s42600-020-00046-y
Colomer A, Igual J, Naranjo V (2020) Detection of early signs of diabetic retinopathy based on textural and morphological information in fundus images. Sensors (switzerland) 20(4):1–21. https://doi.org/10.3390/s20041005
El-Latif AA, Abd-El-Atty B, Venegas-Andraca SE (2019) A novel image steganography technique based on quantum substitution boxes. Opt Laser Technol 116:92–102. https://doi.org/10.1016/j.optlastec.2019.03.005
Erwin, & Ningsih, D. R. (2020) Improving retinal image quality using the contrast stretching, histogram equalization, and CLAHE methods with median filters. IJ Image Grap Sign Process 2:30–41. https://doi.org/10.5815/ijigsp.2020.02.04
Gandhimathi S, Pillai K (2018) Detection of neovascularization in proliferative diabetic retinopathy fundus images. Int Arab J Inform Technol 15(6):1000–1009
Islam SMS, Hasan MM, Abdullah S (2018) Deep learning based early detection and grading of diabetic retinopathy using retinal fundus images. ArXiv, 23: 1–13. Retrieved from http://arxiv.org/abs/1812.10595
Khalifa NEM, Loey M, Taha MHN, Mohamed HNET (2019) Deep transfer learning models for medical diabetic retinopathy detection. Acta Informatica Medica 27(5):327–332. https://doi.org/10.5455/aim.2019.27.327-332
Krishnamoorthy S, Shanthini A, Manogaran G, Saravanan V, Manickam A, Samuel RD (2021) Regression model-based feature filtering for improving hemorrhage detection accuracy in diabetic retinopathy treatment. Int J Uncertain Fuzz Know Based Syst 29(Supp01):51–71. https://doi.org/10.1142/s0218488521400031
Masood S, Luthra T, Sundriyal H, Ahmed M (2017) Identification of diabetic retinopathy in eye images using transfer learning. Proceeding—IEEE international conference on computing, communication and automation, ICCCA 2017, 2017-Janua (May 2017), 1183–1187. https://doi.org/10.1109/CCAA.2017.8229977
Mateen M, Wen J, Nasrullah N, Sun S, Hayat S (2020) Exudate detection for diabetic retinopathy using pretrained convolutional neural networks. Hindwai Complex 2020:1–11. https://doi.org/10.1155/2020/5801870
Mondal SS, Mandal N, Singh A, Singh KK (2020) Blood vessel detection from Retinal fundas images using GIFKCN classifier. Proc Comput Sci 167:2060–2069. https://doi.org/10.1016/j.procs.2020.03.246
Noah Akande O, Christiana Abikoye O, Anthonia Kayode A, Lamari Y (2020) Implementation of a framework for healthy and diabetic retinopathy retinal image recognition. Hindawi Scientifica 2020(May):1–14. https://doi.org/10.1155/2020/4972527
Pratt H, Coenen F, Broadbent DM, Harding SP, Zheng Y (2016) Convolutional neural networks for diabetic retinopathy. Proc Comput Sci 90:200–205. https://doi.org/10.1016/j.procs.2016.07.014
Qureshi I, Ma J, Shaheed K (2019) A hybrid proposed fundus image enhancement framework for diabetic retinopathy. MDPI Algor 14:1–17. https://doi.org/10.3390/a12010014
Sadikoglu F, Uzelaltinbulat S (2016) Biometric retina identification based on neural network. Proc Comput Sci 102:26–33. https://doi.org/10.1016/j.procs.2016.09.365
Sahu S, Singh AK, Elhoseny M (2018) An approach for de-noising and contrast enhancement of retinal fundus image using CLAHE. Opt Laser Technol. https://doi.org/10.1016/j.optlastec.2018.06.061
Salem N, Malik H, Shams A (2019) Medical image enhancement based on histogram algorithms. Proc Comput Sci 163:300–311. https://doi.org/10.1016/j.procs.2019.12.112
Shanthini A, Manogaran G, Vadivu G, Kottilingam K, Nithyakani P, Fancy C (2021) Threshold segmentation based multi-layer analysis for detecting diabetic retinopathy using convolution neural network. J Ambient Intell Humaniz Comput. https://doi.org/10.1007/s12652-021-02923-5
Takahashi H, Tampo H, Arai Y, Inoue Y, Kawashima H (2017) Applying artificial intelligence to disease staging: Deep learning for improved staging of diabetic retinopathy. PLoS ONE 12(6):1–11. https://doi.org/10.1371/journal.pone.0179790
Wang N, Li Q, El-Latif AA (2012) An accurate iris location method for low quality iris images. Fourth international conference on digital image processing (ICDIP 2012). doi:https://doi.org/10.1117/12.946095
Wang N, Li Q, El-Latif AA, Zhang T, Niu X (2012b) Toward accurate localization and high recognition performance for noisy iris images. Multimed Tools Appl 71(3):1411–1430. https://doi.org/10.1007/s11042-012-1278-7
X-ray C, Rahman T, Chowdhury MEH, Khandakar A (2020) Transfer learning with deep convolutional neural network (CNN) for pneumonia detection using chest X-ray. MDPI Appl Sci (10).
Xu K, Feng D, Mi H (2017) Deep convolutional neural network-based early automated detection of diabetic retinopathy using fundus image. Molecules 22(12):2054. https://doi.org/10.3390/molecules22122054
Yuvaraj D, Hariharan S (2016) Content-based image retrieval based on integrating region segmentation and colour histogram. Int Arab J Inform Technol 13(1A):203–207
Acknowledgements
Authors are grateful to Dr.Ramesh’s Super Eye Care & Laser Center, Ludhiana, Punjab, India for providing us the clinical dataset of retinal images of patients. Authors are also thankful IKG PTU, Kapurthala, India for providing us the opportunity to carry out this research work.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
None of the authors has any potential conflict of interest.
Additional information
Communicated by Vicente Garcia Diaz.
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
About this article
Cite this article
Kaur, M., Kamra, A. Detection of retinal abnormalities in fundus image using transfer learning networks. Soft Comput 27, 3411–3425 (2023). https://doi.org/10.1007/s00500-021-06088-3
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00500-021-06088-3