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Daily practice evaluation of the paediatric set of a next-generation long-term haemodialysis machine

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Abstract

Background

From 2006 to 2020, 24% of children starting haemodialysis in France weighed < 20 kg. Most new-generation long-term haemodialysis machines do not propose paediatric lines anymore but Fresenius has validated two devices for use in children above 10 kg. Our aim was to compare the daily use of these two devices in children < 20 kg.

Methods

Retrospective single-center evaluation of daily practice with Fresenius 6008® machines, and low-volume paediatric sets (83 mL), as compared to 5008® machines with paediatric lines (108 mL). Each child was treated randomly with both generators.

Results

A total of 102 online haemodiafiltration sessions were performed over 4 weeks in five children (median body weight 12.0 [range 11.5–17.0] kg). Arterial aspiration and venous pressures were maintained respectively over − 200 mmHg and under 200 mmHg. For all children, blood flow and volume treated per session were lower with 6008® vs. 5008® (p < 0.001), median difference between the two devices being 21%. In the four children treated in post-dilution mode, substituted volume was lower with 6008® (p < 0.001, median difference: 21%). Effective dialysis time was not different between the two generators; however, the difference between total duration of session and dialysis effective time was slightly higher (p < 0.05) with 6008® for three patients, due to treatment interruptions.

Conclusion

These results suggest that children between 11 and 17 kg should be treated with paediatric lines on 5008® if possible. They advocate for modification of the 6008 paediatric set to decrease resistance to blood flow. The possibility to use 6008® with paediatric lines in children below 10 kg deserves further studies.

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Acknowledgements

The authors thank Pr Rukshana Shroff and Mrs Lynsey Stronach, Great Ormond Street Hospital, London (UK), for sharing their experience on the use of 6008 devices and to Dr Mathilde Lassalle from the Réseau Epidemiologique et Information en Néphrologie (REIN) registry for data extraction.

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Authors and Affiliations

  1. Pediatric Nephrology Unit, Hôpital Femme Mère Enfant, Hospices Civils de Lyon, Université de Lyon, European Rare Kidney Disease Reference Network Center, 59 Boulevard Pinel, 69677, Bron Cedex, Lyon, France

    Melodie Mosca, Alida Kouajip-Mabou, Aurelie De Mul, Sarra Rachedi, Justine Bacchetta & Bruno Ranchin

  2. Faculté de Médecine Lyon Est, Université de Lyon, Lyon, France

    Justine Bacchetta

  3. UMR 1033, Faculté de Médecine Lyon Est, INSERM, Université de Lyon, Lyon, France

    Justine Bacchetta

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  1. Melodie Mosca
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  2. Alida Kouajip-Mabou
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Correspondence to Bruno Ranchin.

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Mosca, M., Kouajip-Mabou, A., De Mul, A. et al. Daily practice evaluation of the paediatric set of a next-generation long-term haemodialysis machine. Pediatr Nephrol 38, 3863–3866 (2023). https://doi.org/10.1007/s00467-023-05943-9

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  • DOI: https://doi.org/10.1007/s00467-023-05943-9

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