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Neonatal hypertension: an educational review

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Abstract

Hypertension is encountered in up to 3% of neonates and occurs more frequently in neonates requiring hospitalization in the neonatal intensive care unit (NICU) than in neonates in newborn nurseries or outpatient clinics. Former NICU neonates are at higher risk of hypertension secondary to invasive procedures and disease-related comorbidities. Accurate measurement of blood pressure (BP) remains challenging, but new standardized methods result in less measurement error. Multiple factors contribute to the rapidly changing BP of a neonate: gestational age, postmenstrual age (PMA), birth weight, and maternal factors are the most significant contributors. Given the natural evolution of BP as neonates mature, a percentile cutoff of 95% for PMA has been the most common definition used; however, this is not based on outcome data. Common causes of neonatal hypertension are congenital and acquired renal disease, history of umbilical arterial catheter placement, and bronchopulmonary dysplasia. The treatment of neonatal hypertension has mostly been off-label, but as evidence accumulates, the safety of medical management has increased. The prognosis of neonatal hypertension remains largely unknown and thankfully most often resolves unless secondary to renovascular disease, but further research is needed. This review discusses important factors related to neonatal hypertension including BP measurement, determinants of BP, and management of neonatal hypertension.

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Abbreviations

AKI:

Acute kidney injury

AWAKEN:

Assessment of Worldwide Acute Kidney Injury Epidemiology in Neonates

BP:

Blood pressure

BPD:

Bronchopulmonary dysplasia

IV:

Intravenous

MRI:

Magnetic resonance imaging

NICU:

Neonatal intensive care unit

PMA:

Postmenstrual age

SGA:

Small for gestational age

UAC:

Umbilical arterial catheter

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Acknowledgments

We would like to acknowledge Kate O’Hara, B. Med Sci, M. Pharm, Lead Pharmacist of the Division of Women, Youth and Children, for her contribution to Table 5 of the manuscript.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Neonatology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA

    Matthew W. Harer

  2. Department of Neonatology, Centenary Hospital for Women and Children, Canberra Hospital, P.O. Box 11, Woden, ACT, 2606, Australia

    Alison L. Kent

  3. Australian National University Medical School, Canberra, Australia

    Alison L. Kent

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  1. Matthew W. Harer
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Correspondence to Alison L. Kent.

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1. d; 2. d; 3. a; 4. c; 5. a

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Harer, M.W., Kent, A.L. Neonatal hypertension: an educational review. Pediatr Nephrol 34, 1009–1018 (2019). https://doi.org/10.1007/s00467-018-3996-1

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