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Biomarkers to detect rejection after kidney transplantation

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Abstract

Detecting acute rejection in kidney transplantation has been traditionally done using histological analysis of invasive allograft biopsies, but this method carries a risk and is not perfect. Transplant professionals have been working to develop more accurate or less invasive biomarkers that can predict acute rejection or subsequent worse allograft survival. These biomarkers can use tissue, blood or urine as a source. They can comprise individual molecules or panels, singly or in combination, across different components or pathways of the immune system. This review highlights the most recent evidence for biomarker efficacy, especially from multicenter trials.

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  1. Division of Pediatric Nephrology, Hypertension and Pheresis, Washington University in St Louis & St. Louis Children’s Hospital, St Louis, MO, USA

    Vikas R. Dharnidharka

  2. Division of Nephrology, Washington University School of Medicine, St Louis, MO, USA

    Andrew Malone

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Dharnidharka, V.R., Malone, A. Biomarkers to detect rejection after kidney transplantation. Pediatr Nephrol 33, 1113–1122 (2018). https://doi.org/10.1007/s00467-017-3712-6

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