Abstract
Background
Early management of congenital nephrotic syndrome invariably includes the frequent administration of intravenous human albumin solution. The safety and feasibility of intravenous administration of albumin in the patients’ home setting has not previously been reported.
Case-Diagnosis/Treatment
We report a series of seven paediatric patients whose parents were trained in the administration of albumin via a central venous catheter at home, with the aim of minimising hospital admission or attendances. We describe the clinical course of these patients and complication rates ascribed to this strategy.
Conclusions
Our results demonstrate that home albumin infusion can be performed safely.
Similar content being viewed by others
References
Pleasant LD, Kiessling SD (2014) Kidney and urinary tract diseases in the newborn. In: Chisthti AS, Alam S, Kiessling SG (eds) Congenital nephrotic syndrome. Springer, Berlin, pp 275–286
Kari JA, Montini G, Bockenhauer D, Brennan E, Rees L, Trompeter RS, Tullus K, Van’t Hoff W, Waters A, Ashton E, Lench N, Sebire NJ, Marks SD (2014) Clinico-pathological correlations of congenital and infantile nephrotic syndrome over twenty years. Pediatr Nephrol 29:2173–2180
Coulthard MG (1989) Management of Finnish congenital nephrotic syndrome by unilateral nephrectomy. Pediatr Nephrol 3:451–453
Jalanko H (2009) Congenital nephrotic syndrome. Pediatr Nephrol 24:2121–2128
Holmberg C, Antikainen M, Ronnholm K, Rönnholm K, Ala Houhala M, Jalanko H (1995) Management of congenital nephrotic syndrome of the Finnish type. Pediatr Nephrol 9:87–93
Pruthi R, O’Brien C, Casula A, Braddon F, Lewis M, Maxwell H, Stojanovic J, Tse Y, Inward C, Sinha MD (2013) UK renal registry 16th annual report: chapter 7 demography of the UK paediatric renal replacement therapy population in 2012. Nephron Clin Pract 125:127–138
Machuca E, Benoit G, Nevo F, Tete M-J, Gribouva O, Pawtowski A, Brandström P, Loirat C, Niaudet P, Gubler MC, Antignac C (2010) Genotype-phenotype correlations in non-Finnish congenital nephrotic syndrome. J Am Soc Nephrol 21:1209–1217
Wong W, Morris MC, Kara T (2013) Congenital nephrotic syndrome with prolonged renal survival without renal replacement therapy. Pediatr Nephrol 28:2313–2321
Colomb V, Dabbas-Tyan M, Taupin P, Colomb V, Dabbas-Tyan M, Taupin P (2007) Long-term outcome of children receiving home parenteral nutrition: a 20-year single-center experience in 302 patients. J Pediatr Gastroenterol Nutr 44:347–353
Nazer D, Abdulhamid I, Thomas R, Pendleton S (2006) Home versus hospital intravenous antibiotic therapy for acute pulmonary exacerbations in cystic fibrosis. Pediatr Pulmonol 41:744–749
Gittins NS, Hunter-Blair YL, Matthews JNS, Coulthard MG (2007) Comparison of alteplase and heparin in maintaining the patency of paediatric central venous haemodialysis lines: a randomised controlled trial. Arch Dis Child 92:499–501
Moore DL, Bortolussi R (2011) Home intravenous therapy: accessibility for Canadian children and youth. Pediatr Child Health 16:105–109
Howard K, Salkeld G, White S, McDonald S, Chadban S, Craig JC, Cass A (2009) The cost-effectiveness of increasing kidney transplantation and home-based dialysis. Nephrology 14:123–132
Rozga J, Piatek T, Malkowski P (2013) Human albumin: old, new and emerging applications. Ann Transplant 18:205–217
Acknowledgments
The commencement of the home albumin programme would not have been possible without the enthusiasm and foresight of Dr. Malcolm Coulthard.
Conflict of interest
The authors declare that they have no conflicts of interest.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Reynolds, B.C., Pickles, C.W., Lambert, H.J. et al. Domiciliary administration of intravenous albumin in congenital nephrotic syndrome. Pediatr Nephrol 30, 2045–2050 (2015). https://doi.org/10.1007/s00467-015-3177-4
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00467-015-3177-4