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Renovascular hypertension due to antithrombin deficiency in childhood

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Abstract

Inherited antithrombin deficiency generally causes a predisposition toward vascular thrombus above the age of 15 years. A 1-year-old boy developed renal hypertension caused by renal artery obstruction due to thrombus formation. This thrombus formation was attributed to antithrombin deficiency caused by a novel SERPINC1 gene mutation (AT III Akita, M352R). This suggests that antithrombin deficiency can cause renal artery obstruction, inducing renal hypertension through vascular thrombosis even in children.

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References

  1. Stanley JC, Fry WJ (1981) Pediatric renal artery occlusive disease and renovascular hypertension: etiology, diagnosis, and operative treatment. Arch Surg 116:669–676

    Google Scholar 

  2. Tollefsen DM (2001) Antithrombin deficiency. In: Scriver CR, Beaudet AL, Valle D, Sly WS (eds) The metabolic and molecular bases of inherited disease. McGraw Hill, New York, pp 4455–4471

  3. Demers C, Ginsberg JS, Hirsh J, HendersonP, Blajchman MA (1992) Thrombosis in antithrombin-III-deficient persons. Report of a large kindred and literature review. Ann Intern Med 116:754–761

    CAS  PubMed  Google Scholar 

  4. Shapiro ME, Rodvien R, Bauer KA, Salzman EW (1981) Acute aortic thrombosis in antithrombin III deficiency. JAMA 245:1759–1761

    Article  CAS  PubMed  Google Scholar 

  5. Winter JH, Bennet B, Douglas AS (1982) Aortic thrombosis in antithrombin III deficiency. JAMA 247:1127–1128

    CAS  Google Scholar 

  6. Candrina R, Goppini A, Salvi A, Zuccato F, Giustina G (1986) Arterial thrombosis in antithrombin III deficiency. Clin Lab Haematol 8:267–268

    CAS  PubMed  Google Scholar 

  7. Picard V, Dautzenberg M-D, Viloutreix BO, Orliaguet G, Alhenc-Gelas M, Aiach M (2003) Antithrombin Phe229Leu: a new homozygous variant leading to spontaneous antithrombin polymerization in vivo associated with severe childhood thrombosis. Blood 102:919–925

    Article  CAS  PubMed  Google Scholar 

  8. Mitchell L, Piovella F, Ofosu F, Andrew M (1991) α-2-Macroglobulin may provide protection from thromboembolic events in antithrombin III-deficient children. Blood 78:2299–2304

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Akita University School of Medicine, 010–8543, Akita, Japan

    Kaori Miura, Tsutomu Takahashi, Ikuko Takahashi, Masaki Komatsu, Satoko Tsuchida, Tamaki Mikami & Goro Takada

  2. Department of Radiology, Akita University School of Medicine, Akita, Japan

    Satoshi Takahashi

  3. Division of Pediatrics, Yuri General Hospital, Honjo, Japan

    Takashi Suzuki

Authors
  1. Kaori Miura
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  2. Tsutomu Takahashi
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  3. Ikuko Takahashi
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  4. Masaki Komatsu
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  5. Satoko Tsuchida
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  6. Tamaki Mikami
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  7. Takashi Suzuki
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  8. Satoshi Takahashi
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  9. Goro Takada
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Corresponding author

Correspondence to Tsutomu Takahashi.

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Miura, K., Takahashi, T., Takahashi, I. et al. Renovascular hypertension due to antithrombin deficiency in childhood. Pediatr Nephrol 19, 1294–1296 (2004). https://doi.org/10.1007/s00467-004-1592-z

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  • DOI: https://doi.org/10.1007/s00467-004-1592-z

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