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Efficacy and safety of laparoscopic liver resection for hepatocellular carcinoma in segment 8: a propensity score-matched two-center study

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Abstract

Background

The safety and efficacy of laparoscopic liver resection (LLR) have been reported worldwide. However, those of LLR for tumors located in Couinaud’s segment 8 are not sufficiently investigated.

Methods

We retrospectively analyzed 108 patients who underwent liver resection for hepatocellular carcinoma (HCC) in segment 8 at Kobe University Hospital and Hyogo Cancer Center between January 2010 and December 2021. The patients were categorized in LLR and open liver resection (OLR) groups, and 1:1 propensity score matching (PSM) was performed to compare surgical outcomes between the groups.

Results

Forty-seven and 61 patients underwent LLR and OLR, respectively. After PSM, each group contained 34 patients. There was no significant difference in operation time between the groups (331 min vs. 330 min, P = 0.844). Patients in the LLR group had significantly less blood loss (30 mL vs. 468 mL, P < 0.001) and shorter length of postoperative hospital stay (10 days vs. 12 days, P = 0.015) than those in the OLR group. There was no significant difference in the occurrence of postoperative complications between the groups (12% vs. 9%, P = 0.690). Further, the 1-year cumulative incidence of recurrence was not significantly different between the groups (16% vs. 19%, P = 0.734).

Conclusions

The surgical outcomes and short-term prognosis of LLR were similar or better than those of OLR. LLR could be an effective and safe procedure, even for lesions located in segment 8, which is considered a difficult anatomical location for LLR.

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Acknowledgements

We would like to thank S. Murakami MD, PhD (Division of Clinical and Translational Research Center, Kobe University Hospital, Kobe, Japan) for assistance with statistical analysis.

Funding

The authors have no source of funding to declare.

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Authors and Affiliations

  1. Division of Hepato-Biliary-Pancreatic Surgery, Department of Surgery, Graduate School of Medicine, Kobe University, 7-5-2 Kusunoki-Cho, Chuo-Ku, Kobe, 650-0017, Japan

    Nobuaki Yamasaki, Hidetoshi Gon, Toshihiko Yoshida, Masahiro Kido, Shohei Komatsu, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama & Takumi Fukumoto

  2. Department of Surgery, Hyogo Cancer Center, Akashi, Hyogo, Japan

    Hisoka Yamane, Hirotoshi Soyama & Motofumi Tanaka

Authors
  1. Nobuaki Yamasaki
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  2. Hidetoshi Gon
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  3. Hisoka Yamane
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  4. Toshihiko Yoshida
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  5. Hirotoshi Soyama
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  6. Masahiro Kido
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Corresponding author

Correspondence to Hidetoshi Gon.

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Disclosures

Drs. Nobuaki Yamasaki, Hidetoshi Gon, Hisoka Yamane, Toshihiko Yoshida, Hirotoshi Soyama, Masahiro Kido, Motofumi Tanaka, Shohei Komatsu, Daisuke Tsugawa, Hiroaki Yanagimoto, Hirochika Toyama, and Takumi Fukumoto have no conflicts of interest or financial ties to disclose.

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Yamasaki, N., Gon, H., Yamane, H. et al. Efficacy and safety of laparoscopic liver resection for hepatocellular carcinoma in segment 8: a propensity score-matched two-center study. Surg Endosc 37, 8438–8446 (2023). https://doi.org/10.1007/s00464-023-10291-8

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  • DOI: https://doi.org/10.1007/s00464-023-10291-8

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