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Peroral endoscopic myotomy alone is effective for esophageal motility disorders and esophageal epiphrenic diverticulum: a retrospective single-center study

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Abstract

Background

Esophageal epiphrenic diverticulum (ED) is associated with esophageal motility disorder (EMD). If a diverticulum associated with EMD is enlarging with worsening symptoms, surgical intervention, including laparoscopic epiphrenic diverticulectomy with myotomy and fundoplication, is indicated. However, some studies suggest that myotomy alone, with less adverse events, is sufficient to improve symptoms. Additionally, peroral endoscopic myotomy (POEM) is considered effective and safe for EMD. Since theoretically, POEM is endoscopic Heller myotomy, POEM without diverticulectomy is considered a less invasive, promising treatment option for EMD and ED. We aimed to determine the efficacy and safety of POEM alone for ED with EMD.

Methods

This single-center study was retrospective. A total of 298 patients underwent POEM in Kobe University Hospital from April 2015 to October 2018. Of them, 14 patients had ED. Procedure-related outcomes and treatment outcomes 3 months post POEM were evaluated in these patients.

Results

The median maximum ED diameter was 29 (range 9–90) mm; and the median POEM procedure time, 77.5 (range 41–123) min. Pneumoperitoneum, which required needle decompression, occurred in one patient, but no fatal adverse events occurred. The median Eckardt score significantly decreased from 5 [range 2–11] pre POEM to 0 [range 0–2] post POEM (P < 0.0001). The median integrated relaxation pressure significantly decreased from 22.5 [13.9–34.3] mmHg pre POEM to 10.2 [0.7–23.9] mmHg post POEM (P < 0.0001). Of 14 patients, only one patient complained of gastroesophageal reflux disease symptoms, which could be controlled with a potassium-competitive acid blocker.

Conclusions

POEM alone seemed effective and safe for patients with EMD and ED.

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Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Division of Gastroenterology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Chu-o-ku, Kusunoki-cho, Kobe, Hyogo, 650-0017, Japan

    Masato Kinoshita, Shinwa Tanaka, Fumiaki Kawara, Hiroya Sakaguchi, Hirofumi Abe, Ryusuke Ariyoshi & Yuzo Kodama

  2. Department of Endoscopy, Kobe University Hospital, Kobe, Japan

    Takashi Toyonaga

Authors
  1. Masato Kinoshita
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  2. Shinwa Tanaka
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  3. Fumiaki Kawara
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  4. Hiroya Sakaguchi
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  5. Hirofumi Abe
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  6. Ryusuke Ariyoshi
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  7. Takashi Toyonaga
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  8. Yuzo Kodama
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Corresponding author

Correspondence to Shinwa Tanaka.

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Disclosures

Drs. Masato Kinoshita, Shinwa Tanaka, Fumiaki Kawara, Hiroya Sakaguchi, Hirofumi Abe, Ryusuke Ariyoshi, Takashi Toyonaga, and Yuzo Kodama have no conflicts of interest.

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Kinoshita, M., Tanaka, S., Kawara, F. et al. Peroral endoscopic myotomy alone is effective for esophageal motility disorders and esophageal epiphrenic diverticulum: a retrospective single-center study. Surg Endosc 34, 5447–5454 (2020). https://doi.org/10.1007/s00464-019-07340-6

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