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15-year experience of laparoscopic gastrectomy in advanced gastric cancer: analysis on short-term and long-term oncologic outcome

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Abstract

Background

Laparoscopic gastrectomy (LG) is now a widely accepted treatment option for gastric cancer. However, there is insufficient evidence for LG for advanced gastric cancer (AGC). Many retrospective studies have shown that LG for AGC is safe and feasible, but very few studies have shown the actual outcome in general practice. The aim of this study is to analyze our last 15 years of experience in LG for AGC.

Methods

This is a retrospective review from May 2003 to May 2017 in Seoul National University Bundang Hospital. A total of 1592 patients who had LG for AGC were enrolled of which 109 patients with open conversion were excluded. We evaluated the short-term and long-term oncologic outcomes of LG for AGC.

Results

A total of 1483 patients were analyzed. There were 432 cases of total gastrectomy, 982 cases of distal gastrectomy, and 69 cases of proximal gastrectomy. The total complication rate was 9.1% (135/1483), which included wound-related complications (0.7%), postoperative bleeding (0.5%), anastomosis or stump leakage (2.2%), intestinal obstruction (0.9%), pancreatic fistula (0.1%), intra-abdominal abscess (1.6%), and lung morbidity (3.0%). The rate of Clavien-Dindo grade 3 and above complications was 4.9%. Age was the only significant risk factor in multivariate analysis (OR 1.02; 95% CI, 1.01–1.04, P = 0.01). 5-year overall survival stratified by stage was as follows: stage IB 88.9%, stage IIA 88.7%, stage IIB 84.2%, stage IIIA 71.7%, stage IIIB 56.8%, stage IIIC 45.4%, and stage IV 25%. Total recurrence rate was 14.4%, which included local recurrence (1.1%) and distant metastases (13.3%).

Conclusions

During our 15 years of experience, we have successfully performed 1483 cases of AGC with laparoscopy. Our results showed short-term and long-term oncologic outcomes that were comparable with other studies. LG is safe and feasible in general practice for advanced gastric cancer when performed by experienced surgeons.

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Author notes

  1. Yoontaek Lee

    Present address: Department of Surgery, Ewha Womans University Seoul Hospital, Seoul, Republic of Korea

Authors and Affiliations

  1. Department of Surgery, Seoul National University Bundang Hospital, 82, Gumi-ro 173 Beon-gil, Bundang-gu, Seongnam-Si, Gyeonggi-Do, 13620, Republic of Korea

    Sa-Hong Min, Yongjoon Won, Guowei Kim, Yoontaek Lee, Young Suk Park, Sang-Hoon Ahn, Do Joong Park & Hyung-Ho Kim

  2. Department of Surgery, Seoul National University College of Medicine, Seoul, Republic of Korea

    Sang-Hoon Ahn, Do Joong Park & Hyung-Ho Kim

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  1. Sa-Hong Min
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Sa-Hong Min, Yongjoon Won, Guowei Kim, Yoontaek Lee, Young Suk Park, Sang-Hoon Ahn, Do Joong Park, and Hyung-Ho Kim have no conflict of interest to disclose.

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Min, SH., Won, Y., Kim, G. et al. 15-year experience of laparoscopic gastrectomy in advanced gastric cancer: analysis on short-term and long-term oncologic outcome. Surg Endosc 34, 4983–4990 (2020). https://doi.org/10.1007/s00464-019-07292-x

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