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Efficacy and safety of endoscopic resection for small submucosal tumors originating from the muscularis propria layer in the gastric fundus

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Abstract

Background

Gastric small submucosal tumors (SMTs) are becoming increasingly common. However, the fundus of stomach is regarded as a difficult area for endoscopic resection (ER). In this study, we investigated the efficacy, safety, and long-term outcomes of ER for small SMTs of the gastric fundus in a large series of patients, research that was previously lacking.

Methods

537 consecutive patients with SMTs no more than 20 mm in diameter, occurring in the gastric fundus and originating from the muscularis propria layer, which were treated with endoscopic submucosal excavation or endoscopic full-thickness resection (EFTR) were included in this retrospective study at Zhongshan Hospital of Fudan University from January 2013 to September 2016. Clinicopathological, endoscopic, and follow-up data were collected and analyzed.

Results

En bloc resection was achieved in 100% of patients, and complete resection was achieved for 530 (98.7%) lesions. Although the total rate of complications was 9.3%, few serious adverse events occurred in only three (0.6%) patients, including major pneumoperitoneum, major hydrothorax, and bleeding. Unlike lager tumor sizes and longer procedure times, endoscopist experience had a positive impact on decreasing the likelihood of complications. Based on statistical analysis, tumors with greater size near the cardia, which were treated by EFTR, were the significant contributors to longer operative times. A median follow-up of 32 months was available, and all patients were free from local recurrence or distant metastasis during the study period.

Conclusions

Although the gastric fundus presents technical difficulties, ER is effective for the resection of small gastric SMTs with a high complete resection rate and rare serious adverse events.

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Funding

This project was supported by the Shanghai Engineering and Research Center of Diagnostic and Therapeutic Endoscopy (16DZ2280900), National Natural Science Foundation of China (81672329), Science and Technology Commission Foundation of Shanghai Municipality (16411950400, 16411950406), and Shanghai Municipal Health System Outstanding Academic Leaders Foundation Program (2017BR010). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

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Author notes

  1. Bing Li, Tao Chen and Zhi-Peng Qi have contributed equally to this paper.

Authors and Affiliations

  1. Endoscopy Center, Zhongshan Hospital of Fudan University, 180 Fenglin Road, Shanghai, 200032, China

    Bing Li, Tao Chen, Zhi-Peng Qi, Li-Qing Yao, Mei-Dong Xu, Qiang Shi, Shi-Lun Cai, Di Sun, Ping-Hong Zhou & Yun-Shi Zhong

  2. Endoscopy Research Institute of Fudan University, Shanghai, 200032, China

    Bing Li, Tao Chen, Zhi-Peng Qi, Li-Qing Yao, Mei-Dong Xu, Qiang Shi, Shi-Lun Cai, Di Sun, Ping-Hong Zhou & Yun-Shi Zhong

Authors
  1. Bing Li
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  2. Tao Chen
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  3. Zhi-Peng Qi
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  4. Li-Qing Yao
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  7. Shi-Lun Cai
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Corresponding authors

Correspondence to Ping-Hong Zhou or Yun-Shi Zhong.

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Disclosures

Bing Li, Tao Chen, Zhi-Peng Qi, Li-Qing Yao, Mei-Dong Xu, Qiang Shi, Shi-Lun Cai, Di Sun, Ping-Hong Zhou, and Yun-Shi Zhong have no conflicts of interest or financial ties to disclose.

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Li, B., Chen, T., Qi, ZP. et al. Efficacy and safety of endoscopic resection for small submucosal tumors originating from the muscularis propria layer in the gastric fundus. Surg Endosc 33, 2553–2561 (2019). https://doi.org/10.1007/s00464-018-6549-6

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  • DOI: https://doi.org/10.1007/s00464-018-6549-6

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