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Predictive factors for lymph node metastasis in early gastric cancer with lymphatic invasion after endoscopic resection

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Abstract

Background

Lymph node (LN) metastasis is found in only about 5–10% of the patients who undergo additional surgery after non-curative endoscopic resection. Lymphatic invasion after endoscopic submucosal dissection (ESD) is regarded as non-curative resection due to risk of reginal LN metastasis. This study was aimed to identify clinicopathologic predictive factors for LN metastasis in early gastric cancer (EGC) with lymphatic invasion after endoscopic resection.

Methods

Among a total of 2036 patients who underwent endoscopic resection for EGC at Samsung Medical Center from April 2000 to May 2011, 146 patients were diagnosed with lymphatic invasion. And 123 patients who had gastrectomy with LN dissection due to presence of lymphatic invasion as one of the non-curative factors were included in this study. Demographics, endoscopic tumor findings, histological findings, surgical findings with pathologic reports, and follow-up data were collected from the patient’s medical records. Pathological re-evaluation of resected specimens was performed.

Results

Among a total of 123 patients, LN metastases were found in seven patients (5.7%). The univariate analysis revealed that the LN metastasis was significantly more frequent in patients with certain morphology of lymphatic invasion that shows adhesion to endothelium of lymphatic tumor emboli (p = 0.016), higher number of lymphatic tumor emboli in whole section (p < 0.001) and papillary adenocarcinoma component (p = 0.024). In multivariate analysis, the number of lymphatic tumor emboli [OR 93.5, 95% CI (2.62–3330.81)] and the presence of papillary adenocarcinoma component [OR 552.5, 95% CI (1.20–254871.81)] were identified as independent predictors of LN metastasis in patients with lymphatic invasion after endoscopic resection.

Conclusions

The number of lymphatic tumor emboli and the presence of papillary adenocarcinoma component were significant predictors for LN metastasis in patients with lymphatic invasion after endoscopic resection.

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Authors and Affiliations

  1. Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-ro, Gangnam-gu, Seoul, 135-710, South Korea

    Ji Won Park, Hyuk Lee, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee & Jae J. Kim

  2. Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea

    Sangjeong Ahn & Kyoung-Mee Kim

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  1. Ji Won Park
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  2. Sangjeong Ahn
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  4. Byung-Hoon Min
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Correspondence to Jae J. Kim.

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Disclosures

Drs Ji Won Park, Sangjeong Ahn, Hyuk Lee, Byung-Hoon Min, MD, Jun Haeng Lee, Poong-Lyul Rhee, Kyoung-Mee Kim, and Jae J. Kim have no conflicts of interest or financial ties to disclose.

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Park, J.W., Ahn, S., Lee, H. et al. Predictive factors for lymph node metastasis in early gastric cancer with lymphatic invasion after endoscopic resection. Surg Endosc 31, 4419–4424 (2017). https://doi.org/10.1007/s00464-017-5490-4

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  • DOI: https://doi.org/10.1007/s00464-017-5490-4

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