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Stem cell transplantation as a progressing treatment for retinitis pigmentosa

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Abstract

Retinal degenerative diseases such as retinitis pigmentosa (RP) are of the major causes of vision loss in developed countries. Despite the unclear pathophysiology, treatment methods have been investigated vastly in the past decades. This review article mainly discusses the advances in application of stem cell and progenitor transplantation for retinitis pigmentosa. Stem cell sources such as mesenchymal stem cells, embryonic stem cells, induced pluripotent stem cells, neural stem cells, retinal progenitor cells, and olfactory ensheathing cells are discussed separately in addition to a brief description of two approaches for treatment of early-stage RP, including gene therapy and nutritional therapy.

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Acknowledgements

The authors would like to appreciate Dr. Shamoei Wang and Dr. Robert MacLaren for their kind cooperation as the expert reviewer.

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Authors and Affiliations

  1. School of Medicine, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Sedighe Hosseini Shabanan, Homa Seyedmirzaei, Sara Hanaei & Nima Rezaei

  2. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran

    Homa Seyedmirzaei, Sara Hanaei & Nima Rezaei

  3. Research Center for Immunodeficiencies, Tehran University of Medical Sciences (TUMS), Tehran, Iran

    Homa Seyedmirzaei, Sara Hanaei & Nima Rezaei

  4. Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY, USA

    Alona Barnea

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Hosseini Shabanan, S., Seyedmirzaei, H., Barnea, A. et al. Stem cell transplantation as a progressing treatment for retinitis pigmentosa. Cell Tissue Res 387, 177–205 (2022). https://doi.org/10.1007/s00441-021-03551-3

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