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Plakophilins and their roles in diseased states

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Abstract

Tissue homeostasis is maintained by several cellular mechanisms and an imbalance may lead to diseased states. Here, the plakophilins 1, 2 and 3 operate as structural components and stabilize desmosomal cell-cell contacts. In their non-junctional states, they serve as regulators of signaling programs and control varied cellular processes that range from transcription, mRNA abundance, protein synthesis, growth, proliferation, migration to invasion and tumor development. Accordingly, mutations in plakophilins 1 and 2 lead to skin or heart diseases. Corresponding to their strong impact on tissue homeostasis, the expression of plakophilins is specifically deregulated in various cancer types and can be correlated with patients’ survival. However, our understanding on how plakophilins contribute to tumor development, progression and metastasis in a given tumor is still in its infancy and further in-depth studies using patient-derived data together with in vitro data and animal models are required.

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Acknowledgments

I thank Werner Franke for his long-lasting and generous support that fostered my development as an independent researcher.

Funding

Funding by the German Cancer Aid (107861, 109248) and the “Deutsche Forschungsgemeinschaft” (HO2455/3-1) is greatly acknowledged.

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Authors and Affiliations

  1. Division of Vascular Oncology and Metastasis, DKFZ-ZMBH Alliance, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

    Ilse Hofmann

  2. Department of Vascular Biology and Tumor Angiogenesis, European Center for Angioscience (ECAS), Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany

    Ilse Hofmann

  3. Genomics and Proteomics Core Facility Unit Antibodies, German Cancer Research Center, Heidelberg, Germany

    Ilse Hofmann

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Correspondence to Ilse Hofmann.

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This review is dedicated to Prof. Dr. Werner W. Franke in honor of his 80th birthday.

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Hofmann, I. Plakophilins and their roles in diseased states. Cell Tissue Res 379, 5–12 (2020). https://doi.org/10.1007/s00441-019-03153-0

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