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Progenitor genealogy in the developing cerebral cortex

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Abstract

The mammalian cerebral cortex is characterized by a complex histological organization that reflects the spatio-temporal stratifications of related stem and neural progenitor cells, which are responsible for the generation of distinct glial and neuronal subtypes during development. Some work has been done to shed light on the existing filiations between these progenitors as well as their respective contribution to cortical neurogenesis. The aim of the present review is to summarize the current views of progenitor hierarchy and relationship in the developing cortex and to further discuss future research directions that would help us to understand the molecular and cellular regulating mechanisms involved in cerebral corticogenesis.

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Acknowledgments

We thank Dr. C. Creppe for providing comments on the manuscript. S.L. and L.N. are, respectively, PhD student and Research Associate from the Belgian National Funds for Scientific Research (F.R.S.-F.N.R.S.). L.N. is funded by grants from the F.R.S.-F.N.R.S., the Fonds Léon Fredericq, the Fondation Médicale Reine Elisabeth, the Belgian Science Policy (IAP-VII network P7/20), and the Actions de Recherche Concertées (ARC11/16-01). Some scientific projects in the Nguyen laboratory are funded by the Walloon Excellence in Life Sciences and Biotechnology (WELBIO). The authors declare no competing financial interests.

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  1. GIGA-Neurosciences, University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium

    Sophie Laguesse, Elise Peyre & Laurent Nguyen

  2. Interdisciplinary Cluster for Applied Genoproteomics (GIGA-R), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium

    Sophie Laguesse, Elise Peyre & Laurent Nguyen

  3. Walloon Excellence in Lifesciences and Biotechnology (WELBIO), University of Liège, C.H.U. Sart Tilman, Liège, 4000, Belgium

    Laurent Nguyen

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Correspondence to Laurent Nguyen.

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Laguesse, S., Peyre, E. & Nguyen, L. Progenitor genealogy in the developing cerebral cortex. Cell Tissue Res 359, 17–32 (2015). https://doi.org/10.1007/s00441-014-1979-5

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