Abstract
The peritoneal cavity has a microenvironment capable of promoting proliferation, differentiation, and activation of the resident cells and recruitment of blood cells through the capillary network involved in the peritoneum. Among the cells found in the peritoneal cavity, B-1 cells are a particular cell type that contains features that are not very well defined. These cells differ from conventional B lymphocytes (B-2) by phenotypic, functional, and molecular characteristics. B-1 cells can produce natural antibodies, migrate to the inflammatory focus, and have the ability to phagocytose pathogens. However, the role of B-1 cells in immunity against parasites is still not completely understood. Several experimental models have demonstrated that B-1 cells can affect the susceptibility or resistance to parasite infections depending on the model and species. Here, we review the literature to provide information on the peculiarities of B-1 lymphocytes as well as their interaction with parasites.
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This work was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo (grant number 2016/17245-4 to P.X.) and the scholarship from Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) and Coordenação de Aperfeiçoamento Pessoal de Ensino Superior (CAPES).
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RRNB and PX conceived and designed the work; RRNB, MST, GML, TVD, and NCR researched the data for the article and wrote the manuscript; ECP revised the final manuscript; and PX reviewed and edited the manuscript before submission. All authors provided substantial contributions to the discussion of the content. All authors have read and approved the final manuscript.
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Novaes e Brito, R.R., dos Santos Toledo, M., Labussiere, G.M. et al. B-1 cell response in immunity against parasites. Parasitol Res 118, 1343–1352 (2019). https://doi.org/10.1007/s00436-019-06211-2
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DOI: https://doi.org/10.1007/s00436-019-06211-2