Abstract
Purpose
When more than two tumors are diagnosed in the same person, it is called multiple primary cancer. It is rare to be diagnosed as four primary cancers. Here, we present one elderly male patient suffered from testicular seminoma, gastric cancer, bladder cancer and breast cancer from 1946 to 2019.
Methods
When he was about 1.5 years old in 1946, his mother (a doctor) inadvertently found that the left scrotum of the child was enlarged. He performed left testicular resection under general anesthesia and postoperative pathological report: left testicular seminoma. In March 2007 (62 years old), the upper abdomen was distended and uncomfortable after eating, accompanied by hiccups and heartburn. He performed distal subtotal gastrectomy and postoperative pathology report: moderately and poorly differentiated adenocarcinoma of ulcer. In May 2013 (68 years old), he developed no obvious cause of painless gross hematuria. He performed robot-assisted laparoscopic radical cystectomy+pelvic lymph node dissection+bilateral ureterostomy and postoperative pathological report: invasive high-grade urothelial carcinoma at the bottom of the bladder. In February 2017 (72 years old), he found the right breast was developing, and a nodule was palpable under the skin. He performed undergo modified radical surgery in the right breast and postoperative pathological report: Invasive breast cancer.
Results
During the past 70 years, he suffered from four types of tumors, all of which underwent surgical treatment. Postoperative pathology confirmed that they were malignant tumors. Genetic tumor gene testing found no pathogenic or suspected pathogenic mutations. The patient’s general condition is good, with regular follow-up and no tumor recurrence
Conclusion
The treatment of multiple primary cancers is different from tumor recurrence. Targeted treatment for different tumors can achieve good therapeutic results. Cancer patients must be followed up regularly. Timely treatment after discovering new tumors is the key to a good prognosis.
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Data availability
All of the data supporting the findings in this study are available upon reasonable request from the corresponding author (Yanxiang Cao).
References
Dieckmann KP, Wegner HE, Krain J (1994) Multiple primary neoplasms in patients with testicular germ cell tumor [J]. Oncology 51(5):450–458
Fosså SD, Langmark F, Aass N et al (1990) Second non-germ cell malignancies after radiotherapy of testicular cancer with or without chemotherapy [J]. Br J Cancer 61(4):639–643
Hisada M, Garber JE, Fung CY et al (1998) Multiple primary cancers in families with Li-Fraumeni syndrome [J]. J Natl Cancer Inst 90(8):606–611
Li FP, Fraumeni JF Jr (1969) Soft-tissue sarcomas, breast cancer, and other neoplasms. A familial syndrome? [J]. Ann Intern Med 71(4):747–752
Ruijs MW, Verhoef S, Rookus MA et al (2010) TP53 germline mutation testing in 180 families suspected of Li-Fraumeni syndrome: mutation detection rate and relative frequency of cancers in different familial phenotypes [J]. J Med Genet 47(6):421–428
Seegobin K, Staggs E, Khawaja R et al (2018) Pilot study on the occurrence of multiple cancers following cancer-related therapy at the University of Florida, Jacksonville (2011–2016) [J]. J Investig Med 66(7):1050–1054
Tanjak P, Suktitipat B, Vorasan N et al (2021) Risks and cancer associations of metachronous and synchronous multiple primary cancers: a 25-year retrospective study [J]. BMC Cancer 21(1):1045
Vogt A, Schmid S, Heinimann K et al (2017) Multiple primary tumours: challenges and approaches, a review [J]. ESMO Open 2(2):e000172
Ward ZJ, Grover S, Scott AM et al (2020) The role and contribution of treatment and imaging modalities in global cervical cancer management: survival estimates from a simulation-based analysis [J]. Lancet Oncol 21(8):1089–1098
Warren S (1932) Multiple primary malignant tumors: a survey of the literature and a statistical study [J]. Ann J Cancer 2(2):e000172
Wood ME, Vogel V, Ng A et al (2012) Second malignant neoplasms: assessment and strategies for risk reduction [J]. J Clin Oncol 30(30):3734–3745
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All the works were performed by Yanxiang Cao. He read and approved the final manuscript.
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Cao, Y. A case of rare metachronous four primary carcinoma. J Cancer Res Clin Oncol 149, 7471–7477 (2023). https://doi.org/10.1007/s00432-023-04692-4
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DOI: https://doi.org/10.1007/s00432-023-04692-4