Abstract
MicroRNAs (miRNAs) are a class of non-coding RNAs that perform post-transcriptional gene regulation. This review focuses on the role of tumor cell-derived miRNAs in the regulation of the tumor microenvironment (TME) via receptor cell recoding, including angiogenesis, expression of immunosuppressive molecules, formation of radiation resistance, and chemoresistance. Furthermore, we discuss the potential of these molecules as adjuvant therapies in combination with chemotherapy, radiotherapy, or immunotherapy, as well as their advantages as efficacy predictors for personalized therapy. MiRNA-based therapeutic agents for tumors are currently in clinical trials, and while challenges remain, additional research on tumor-derived miRNAs is warranted, which may provide significant clinical benefits to cancer patients.
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This work was supported by the National Natural Science Foundation project (81560430), Guangxi Natural Science Foundation project (2016JJA140484, 2021GXNSFBA075005 and 2018GXNSFBA294007), Liuzhou Science and Technology Plan Project (2020NBAB0827 and 2020NBAB0820), and Liuzhou People’s Hospital Introduces High- Level Talent Scientific Research Start-up Fund Project (LRYGCC202206 and LRYGCC202102).
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qiuxing meng, yaoming deng, yu lu, and chunfeng wu wrote the main manuscript text, and qiuxing meng prepared figures 1-2. All authors reviewed the manuscript.
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Meng, Q., Deng, Y., lu, Y. et al. Tumor-derived miRNAs as tumor microenvironment regulators for synergistic therapeutic options. J Cancer Res Clin Oncol 149, 423–439 (2023). https://doi.org/10.1007/s00432-022-04432-0
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DOI: https://doi.org/10.1007/s00432-022-04432-0