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Ovarian metastasis in patients with endometrial cancer: risk factors and impact on survival

  • Original Article – Clinical Oncology
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Abstract

Background

Oophorectomy is generally performed in patients with endometrial cancer despite the rate of ovarian metastasis being relatively low.

Patients and methods

A multicenter retrospective registry-based study was performed in 2329 patients with endometrial cancer. The outcome measures were the incidence of ovarian metastasis and the impact on overall survival.

Results

Median follow-up was performed at 84 months. A total of 2158 women were eligible for analysis, of which 131 (6.1%) had ovarian metastasis. Women with ovarian metastasis were more likely to have > 50% myometrial invasion, undifferentiated nonendometrioid tumors, and lymph and vascular space invasion. The presence of < 50% myometrial invasion, endometrioid histology, well-differentiated cancer, and negative lymph and vascular space invasion were associated with a very low rate (0.5%) of ovarian metastasis. Notably, after matching for tumor histology and grade, myometrial invasion, and lymph and vascular space invasion, ovarian metastasis was not associated with a reduced median overall survival.

Conclusions

Ovarian preservation should be offered to premenopausal women with endometrial cancer in whom myometrial invasion is less than 50%, the histological type is endometrioid and well-differentiated, and lymph and vascular space invasion is not involved.

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Funding

This study was not funded.

Author information

Author notes

  1. Tanja Ignatov and Holm Eggemann have equally contributed.

Authors and Affiliations

  1. Department of Gynecology and Obstetrics, Otto-von-Guericke University, G.-Hauptmann Str. 35, 39108, Magdeburg, Germany

    Tanja Ignatov, Holm Eggemann, Serban Dan Costa & Atanas Ignatov

  2. Institute of Biometry and Medical Informatics, Otto-von-Guericke University, Magdeburg, Germany

    Elke Burger

  3. Department of Gynecology and Obstetrics, University Medical Center Regensburg, Regensburg, Germany

    Olaf Ortmann & Atanas Ignatov

Authors
  1. Tanja Ignatov
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  2. Holm Eggemann
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  3. Elke Burger
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  4. Olaf Ortmann
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  5. Serban Dan Costa
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  6. Atanas Ignatov
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Corresponding author

Correspondence to Atanas Ignatov.

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Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with animals performed by any of the authors. In accordance with the statement of the Research and Ethical Committee of the Otto-von-Guericke University, Magdeburg, Germany, additional individual consent for this analysis was not needed. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Written informed consent was obtained from all patients before treatment. An additional individual consent for this analysis was not needed.

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Ignatov, T., Eggemann, H., Burger, E. et al. Ovarian metastasis in patients with endometrial cancer: risk factors and impact on survival. J Cancer Res Clin Oncol 144, 1103–1107 (2018). https://doi.org/10.1007/s00432-018-2628-2

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  • DOI: https://doi.org/10.1007/s00432-018-2628-2

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