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Cochlear and vestibular involvement in children with IgA vasculitis

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Abstract

In this study, our purpose is to evaluate cochlear and vestibular function in juveniles with IgA vasculitis using audiometry, distortion product otoacoustic emissions, and cervical vestibular evoked myogenic potential (cVEMP) tests. Forty children diagnosed with IgA vasculitis from the pediatry clinic and 40 age- and sex-matched healthy children were evaluated with distortion product otoacoustic emissions, audiometry, and cVEMP test in a tertiary hospital. The audiometry average values for both ears of the IgA vasculitis group and the control subjects were compared, and as a result, median 4.7-dB sensorineural hearing loss (SHL) was found for the IgA vasculitis group compared to the control group at 250 Hz and it was statistically significant (p < 0.001). An average of 6.4-dB SHL was detected at 8000 Hz (p < 0.001). There was a statistically significant difference among IgA vasculitis and control groups regarding measurement results of average p1-n1 latency time of both ears (0.9 ms (ms) increase, p = 0.035). In IgA vasculitis patients, the median amplitude difference of both ears’ average p1 n1 was found to be 5.6 mV, statistically significantly decreased compared to the control group (p = 0.003).

Conclusion: This study, firstly in literature, demonstrated that IgA vasculitis may have association with hearing loss and vestibular dysfunction in children. We think this might be due to autoimmune mechanisms.

What is Known:

• Ig A vasculitis is a leukocytoclastic vasculitis with unknown etiology, involving the skin, joints, gastrointestinal system, kidneys, and rarely other organs.

• No study has been reported for the cochlear and vestibular association of Ig A vasculitis in current literature.

What is New:

• This study demonstrated that Ig A vasculitis may have association with hearing loss in children.

• This study also demonstrated that Ig A vasculitis may have association with vestibular dysfunction in children.

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SPSS version 15.0 program.

Abbreviations

cVEMP:

Cervical vestibular evoked myogenic potential

dB:

Decibel

dBnHL:

Decibels in hearing level

DPOAEs:

Distortion product otoacoustic emissions

HSV:

Henoch-Schönlein vasculitis

ms:

Millisecond

PTA:

Pure-tone average

SCM:

Sternocleidomastoid muscle

SHL:

Sensorineural hearing loss

SNR:

Signal to noise ratio

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Authors and Affiliations

  1. Otorhinolaryngology Department, Otorhinolaryngology Clinic, Afyonkarahisar Health Sciences University Medical Faculty, 03300, Afyonkarahisar, Turkey

    Abdulkadir Bucak, Selçuk Kuzu & Çağlar Günebakan

  2. Pediatry Department, Afyonkarahisar Health Sciences University Medical Faculty, Afyonkarahisar, Turkey

    Ayşegül Bükülmez

  3. Otorhinolaryngology Department, Şuhut State Hospital, Afyonkarahisar, Turkey

    Erkan Yıldız

  4. Otorhinolaryngology Department, Afyonkarahisar State Hospital, Afyonkarahisar, Turkey

    Abdullah Kınar

Authors
  1. Abdulkadir Bucak
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  2. Ayşegül Bükülmez
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  3. Selçuk Kuzu
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  4. Çağlar Günebakan
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  5. Erkan Yıldız
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  6. Abdullah Kınar
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Contributions

Conceptualization: SK, AB, ABü. Data curation: ÇG, AB, SK. Formal analysis: ÇG, EY, AK. Methodology: SK, AB, AK. Project administration: SK, ABü, EY. Visualization: ÇG, AB, EY. Writing—original draft: SK, AK, EY. Writing—review and editing: SK, ÇG, ABü.

Corresponding author

Correspondence to Selçuk Kuzu.

Ethics declarations

Ethics approval

All procedures performed in this study were following the ethical standards of the University Ethical Committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards (ethical approval registration number: 2017/11–284).

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Informed consent was obtained from all individual participants included in the study.

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Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare no competing interests.

Additional information

Communicated by Peter de Winter

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Bucak, A., Bükülmez, A., Kuzu, S. et al. Cochlear and vestibular involvement in children with IgA vasculitis. Eur J Pediatr 181, 1481–1486 (2022). https://doi.org/10.1007/s00431-021-04331-5

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  • DOI: https://doi.org/10.1007/s00431-021-04331-5

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