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There is no association between vitamin D status and characteristics of central precocious puberty in girls

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Abstract

Vitamin D deficiency has been associated with several pathologies in humans and has recently been linked to idiopathic central precocious puberty in girls. We evaluated this potential link in a retrospective study. Among 493 girls with idiopathic central precocious puberty previously described, we selected 145 girls for whom a plasma sample at the initial evaluation was available to determine the concentration of 25OHD and 1,25(OH)2D. We analyzed the correlation between different puberty characteristics (BMI, growth rate the year before the onset of puberty, bone age, LH and FSH peaks, LH/FSH peak ratio, and estradiol concentration) and the concentration of 25OHD and 1,25(OH)2D. The mean 25OHD serum concentration was 27.6±17.3 ng/mL. Eleven percent of the patients had a severe vitamin D deficiency, 18.6% had a moderate deficiency, 39.4% had an optimal vitamin D status, and 31% had a 25OHD concentration above 30 ng/mL. Season was the only factor that appeared to influence the 25OHD concentration. No correlation was found between 25OHD serum concentration and different puberty characteristics.

Conclusion: Overall, our patients had a satisfactory vitamin D status. We did not find any correlation between vitamin D status and the characteristics of central precocious puberty. Further studies are required to confirm this hypothesis.

What is known:

• Vitamin D status seems to affect gonadal hormones and fertility.

• Vitamin D deficiency may contribute to earlier puberty and was associated with earlier menarche.

What is new:

• 25OHD of 145 girls with precocious puberty was similar to or higher than that of healthy French children or adolescents.

• We did not find any correlation between vitamin D status and puberty characteristics.

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Abbreviations

1,25(OH)2D:

1,25-Dihydroxyvitamin D

25OHD:

25-Hydroxyvitamin D

BA:

Bone age

BMI:

Body mass index

CPP:

Central precocious puberty

FSH:

Follicle-stimulating hormone

GnRH:

Gonadotropin hormone releasing hormone

LH:

Luteinizing hormone

SDS:

SD scores

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Authors and Affiliations

  1. Fondation Ophtalmologique Adolphe de Rothschild and Université Paris Descartes, 75940, Paris, France

    Gwénaëlle Duhil de Bénazé & Raja Brauner

  2. Hôpital Necker-Enfants Malades, Service d’Explorations Fonctionnelles, Assistance Publique-Hôpitaux de Paris, 75743, Paris, France

    Jean-Claude Souberbielle

Authors
  1. Gwénaëlle Duhil de Bénazé
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  2. Raja Brauner
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  3. Jean-Claude Souberbielle
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Contributions

Gwénaëlle Duhil de Bénazé collected and analyzed the data. Raja Brauner conceptualized and designed the study. Jean-Claude Souberbielle performed the biological and statistical analyses, and largely drafted the Discussion. All authors participated to the draft of the manuscript, and read and approved its final version.

Corresponding author

Correspondence to Raja Brauner.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

Written informed consent for the evaluations was obtained from the children’s parents and included in their hospital medical records. All clinical investigations were conducted according to the principles expressed in the Declaration of Helsinki. Patient information was anonymized prior to analysis.

The Comité de Protection des Personnes Ile de France III testified that our study on girls with idiopathic central precocious puberty “appears to be in accordance with the Scientifics principles generally accepted and to the ethical standards of research; the study was lead in the respect of the French law and regulation”, Certificate no. AC 0016.

Additional information

Communicated by Mario Bianchetti

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Duhil de Bénazé, G., Brauner, R. & Souberbielle, JC. There is no association between vitamin D status and characteristics of central precocious puberty in girls. Eur J Pediatr 176, 1677–1680 (2017). https://doi.org/10.1007/s00431-017-3022-9

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  • DOI: https://doi.org/10.1007/s00431-017-3022-9

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