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Efficacy of colchicine in a child with relapsing bullous Henoch-Schönlein purpura

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Abstract

Colchicine is not usually considered a treatment option for cutaneous lesions of Henoch-Schönlein purpura (HSP) in children. We report a case of pediatric HSP with severe chronic and relapsing cutaneous manifestations that were resistant to corticosteroids. Colchicine had remarkable therapeutic efficacy, with positive dechallenge and rechallenge, without any adverse effects.

Conclusion: Colchicine should be considered for chronic, severe cutaneous lesions of pediatric HSP.

What is Known:

• Colchicine is not usually considered a treatment option for cutaneous lesions of Henoch-Schönlein purpura (HSP) in children.

What is New:

• We report a case of pediatric HSP with severe cutaneous manifestations that responded well to colchicine.

• Colchicine should be considered for chronic cutaneous lesions of HSP in children.

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Abbreviations

FMF:

Familial Mediterranean fever

HSP:

Henoch-Schönlein purpura

IgA:

Immunoglobulin A

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Compliance with ethical standards

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Conflict of interest

The authors declare that they have no competing interests.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

Informed consent

Informed consent was obtained from the parents of the patient for publication of this case report.

Authors’ contributions

All authors took part in the management of the patient: Martin Chalumeau and Slimane Allali were in charge of the clinical management. Christine Bodemer and Sylvie Fraitag helped to perform and analyze the skin biopsy. Benjamin Terrier, Christine Bodemer, and Sylvie Fraitag provided advice on the clinical management. All authors took part in the writing of the manuscript. All authors read and approved the final manuscript.

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Authors and Affiliations

  1. Department of General Pediatrics, Hôpital Necker–Enfants Malades, APHP, Paris Descartes University, 149 rue de Sèvres, 75015, Paris, France

    Slimane Allali & Martin Chalumeau

  2. Department of Pathology, Hôpital Necker–Enfants Malades, APHP, Paris Descartes University, 149 rue de Sèvres, 75015, Paris, France

    Sylvie Fraitag

  3. Department of Internal Medicine, Hôpital Cochin, APHP, Paris Descartes University, 27 rue du Faubourg Saint-Jacques, 75014, Paris, France

    Benjamin Terrier

  4. Department of Dermatology, Hôpital Necker–Enfants Malades, APHP, Paris Descartes University, 149 rue de Sèvres, 75015, Paris, France

    Christine Bodemer

Authors
  1. Slimane Allali
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  2. Sylvie Fraitag
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  3. Benjamin Terrier
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  4. Christine Bodemer
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  5. Martin Chalumeau
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Corresponding author

Correspondence to Slimane Allali.

Additional information

Communicated by Mario Bianchetti

Revisions received: 24 June 2015 / 05 July 2015

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Allali, S., Fraitag, S., Terrier, B. et al. Efficacy of colchicine in a child with relapsing bullous Henoch-Schönlein purpura. Eur J Pediatr 175, 147–149 (2016). https://doi.org/10.1007/s00431-015-2594-5

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  • DOI: https://doi.org/10.1007/s00431-015-2594-5

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