Skip to main content
SpringerLink
Log in

The effects of vibration on the neuronal activity of lateral vestibular nuclei in unilaterally labyrinthectomized rats

  • Original Article
  • Published:
Brain Structure and Function Aims and scope Submit manuscript

Abstract

Unilateral labyrinthectomy causes distinct oculomotor and postural disorder syndromes that gradually deteriorate. Simultaneously, compensatory mechanisms for the suppression of pathological disorders were activated. The current study aimed to investigate the characteristics of impulse activity in the ipsilateral and contralateral neurons of the lateral vestibular nucleus of unilaterally labyrinthectomized rats during various periods of vibration exposure. A program analysis of the background impulse activity of the neurons in the right- and left-lateral vestibular nuclei of rats under normal condition and after right-sided labyrinthectomy was performed. The animals were subjected to different periods of vibration exposure 2 days after surgery (5-, 10-, and 15-day periods). A comparison of the characteristics of the background impulse activity of neurons in both nuclei of intact rats revealed an initial asymmetry in the values of the mean impulse frequency and coefficient of variation of interimpulse intervals. After 5 days of vibration exposure, the values of the mean impulse frequency of neurons in both Deiters’ nuclei were almost equal in labyrinthectomized rats. The mean impulse frequency of neurons on the uninjured side was higher than that on the injured side on the days following vibration exposure. The characteristics and functional significance of the findings are discussed.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

Availability of data and materials

Raw data can be provided upon request to the corresponding author.

References

  • Abad-Alegria F (1971) Esterotaxistroncoencefalica. Trab Inst Cajalinvest Biol 63(1):193–224

    Google Scholar 

  • Beraneck M, Hachemaoui M, Idoux E, Ris L et al (2003) Long-term plasticity of ipsilesional medial vestibular nucleus neurons after unilateral labyrinthectomy. J Neurophysiol 84(4):515–526

    Google Scholar 

  • Besnard S, Machado ML, Vignaux G, Boulouard M, Coquerel A, Bouet V, Freret T, Denise P, Lelong-Boulouard V (2012) Influence of vestibular input on spatial and nonspatial memory and on hippocampal NMDA receptors. Hippocampus 22(4):814–826

    Article  CAS  PubMed  Google Scholar 

  • Cameron SA, Dutia MB (1997) Cellular basis of vestibular compensation: changes in intrinsic excitability of MVN neurones. NeuroReport 8(11):2595–2599

    Article  CAS  PubMed  Google Scholar 

  • Cass SP, Kartush JM, Graham MD (1992) Patterns of vestibular function following vestibular nerve section. Laryngoscope 102(4):388–394

    Article  CAS  PubMed  Google Scholar 

  • Cullen KE, Minor LB, Beraneck M, Sadeghi SG (2009) Neural substrates underlying vestibular compensation: contribution of peripheral versus central processing. J Vestib Res 19(5–6):171–182

    PubMed  PubMed Central  Google Scholar 

  • Curthoys IS, Halmagyi GM (1995) Vestibular compensation: a review of the oculomotor, neural, and clinical consequences of unilateral vestibular loss. J Vestib Res 5(2):67–107

    Article  CAS  PubMed  Google Scholar 

  • Curthoys IS, Halmagyi GM (1998) Vestibular compensation: a review of the oculomotor neural and clinical consequences of unilateral vestibular loss. J. Vestibul. Res. 5:67–107

    Article  Google Scholar 

  • Darlington CL, Smith PF (1996) The recovery of static vestibular function following peripheral vestibular lesions in mammals: the intrinsic mechanism hypothesis. J Vestib Res 6(3):185–201

    Article  CAS  PubMed  Google Scholar 

  • Dieringer N, Precht W (1979) Mechanisms of compensation for vestibular deficits in the frog. I Modification of the excitatory commissural system. Exp Brain Res 36(2):311–328

    Article  CAS  PubMed  Google Scholar 

  • Galiana HL, Flohr H, Jones GH (1984) A revalution of intervestibular nuclear copling: its role in vestibular compensation. J Neurophysiol 51:242–259

    Article  CAS  PubMed  Google Scholar 

  • Hamann KF, Lannou J (1987) Dynamic characteristics of vestibular nuclear neurons responses to vestibular and optokinetic stimulation during vestibular compensation in the rat. Acta Otolaryngol Suppl 445:1–19

    CAS  PubMed  Google Scholar 

  • Jenkins H, Cohen H, Kimball K (2000) Long-term vestibulo-ocullar reflex changes in patients with vestibular ablation. Actaoto-Laryngologica. 120(2):187–191

    Article  CAS  Google Scholar 

  • Jones SM, Jones TA, Mills KN, Gaines GC (2009) Anatomical and physiological considerations in vestibular dysfunction and compensation. Semin Hear 30(4):231–241

    Article  PubMed  Google Scholar 

  • Maioli C, Precht W, Ried S (1983) Short- and long-term modifications of vestibulo-ocular response dynamics following unilateral vestibular nerve lesions in the cat. Exp Brain Res 50(2–3):259–274

    CAS  PubMed  Google Scholar 

  • Ris L, de Waele C, Serafin M, Vidal P, Godaux E (1995) Neuronal activity in the ipsilateral vestibular nucleus following unilateral labyrinthectomy in the alert guinea pig. J. Neurophysiology. 74:2087–2099

    Article  CAS  PubMed  Google Scholar 

  • Sadeghi SG, Minor LB, Cullen KE (2007) Response of vestibular-nerve afferents to active and passive rotations under normal conditions and after unilateral labyrinthectomy. J Neurophysiol 97(2):1503–1514

    Article  PubMed  Google Scholar 

  • Sarkisian VH (2000) Input-output relations of Deiter’s lateral vestibulospinal neurons with different structures of the brain. Arch Italiennes De Biologie. 138:295–353

    CAS  Google Scholar 

  • Sarkisyan SH, Chavushyan VA, Kamenecki VS et al (2015) The effects of the stimulation of hypothalamic nuclei on the inferior vestibular nucleus after long-term vibration action and administration of proline rich peptide-1. Russ J Physiol 101(5):538–549

    CAS  Google Scholar 

  • Shaabani M, Lotfi Y, Karimian SM, Rahgozar M, Hooshmandi M (2016) Short-term galvanic vestibular stimulation promotes functional recovery and neurogenesis in unilaterally labyrinthectomized rats. Brain Res 1648(Pt A):152–162

    Article  CAS  PubMed  Google Scholar 

  • Smith PF, Curthoys JS (1988) Neuronal activity in the ipsilateral medial vestibular nucleus of the guinea pig following unilateral labyrinthectomy. Brain Res 444:308–319

    Article  CAS  PubMed  Google Scholar 

  • Vibert N et al (1999) Plastic changes underlying vestibular compensation in the Guinea-pig persist in isolated, in vitro whole brain preparations. Neuroscience 93(2):413–432

    Article  CAS  PubMed  Google Scholar 

  • Vidal PP et al (2005) Recovery after vestibular lesions: from animal models to patients. Neuroembryology and Aging 3(4):194–206

    Article  Google Scholar 

  • Yamanaka T et al (2000) Rapid compensatory changes in GABA receptor efficacy in rat vestibular neurones after unilateral labyrinthectomy. J Physiol 523(2):413–424

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Funding

Not applicable.

Author information

Authors and Affiliations

  1. Department of Human and Animal Physiology, Yerevan State University, Yerevan, Armenia

    S. H. Sarkisyan

  2. Neuroendocrine Relationships Lab, Orbeli Institute of Physiology NAS RA, Yerevan, Armenia

    K. V. Simonyan & V. A. Chavushyan

  3. Histochemistry and Electron Microscopy Lab, Orbeli Institute of Physiology NAS RA, Yerevan, Armenia

    M. H. Danielyan

  4. Sensorimotor Integration Lab, Orbeli Institute of Physiology NAS RA, Yerevan, Armenia

    L. V. Darbinyan

Authors
  1. S. H. Sarkisyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. H. Danielyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. L. V. Darbinyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. V. Simonyan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. V. A. Chavushyan
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

SSH, VAC, and DMH performed the experiments and data analysis. DMH  provided histological interpretation. DLV and KVS provided advice on data interpretation. SSH, VAC, DLV, DMH and KVS wrote the manuscript. All of the authors have contributed substantially to the manuscript.

Corresponding author

Correspondence to K. V. Simonyan.

Ethics declarations

Competing interests

The authors declare no competing interests.

Conflict of interest

The authors declare no conflict of interest.

Ethical approval and consent to participate

The experimental protocol corresponded to the conditions of the European Communities Council Directive (2010/63/ UE) and was approved by the Ethics Committee of Yerevan State Medical University after Mkhitar Heratsi (IRB Approval N4, November 15, 2018).

Consent for publication

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sarkisyan, S.H., Danielyan, M.H., Darbinyan, L.V. et al. The effects of vibration on the neuronal activity of lateral vestibular nuclei in unilaterally labyrinthectomized rats. Brain Struct Funct 228, 463–473 (2023). https://doi.org/10.1007/s00429-022-02588-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00429-022-02588-6

Keywords

Search

Navigation