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Integrative stimulus-specific adaptation of the natural sounds in the auditory cortex of the awake rat

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Abstract

Using oddball stimulus with pure tones, researchers have extensively investigated stimulus-specific adaptation (SSA), which has been regarded as a method of novelty detection, from the inferior colliculus (IC) to the auditory cortex (AC). However, until now, it is not clear whether SSA is preserved for natural sounds or whether it exists for spatial cues in the AC. Moreover, it is also unclear whether SSA integrates different types of cues within a single modality such as sound location and sound identity. Here, we addressed these issues using two natural sounds presented at two different locations while simultaneously performing extracellular recordings in the AC of awake rats. Our data showed that SSA was present in the AC for the natural sounds, the pure tones, and the spatial locations in the neuronal population. We also found that the AC response to a double deviant stimulus (a deviant sound at a deviant location) was stronger than that to a single (either a deviant sound or the same sound at a deviant location); this finding suggests that detecting unexpected events benefits from the integration of different cues within the same modality.

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Abbreviations

SSA:

Stimulus-specific adaptation

AC:

Auditory cortex

IC:

Inferior colliculus

A1:

Primary auditory cortex

AAF:

Anterior auditory filed

CF:

Characteristic frequencies

FRA:

Frequency response area

IOP:

Integrative oddball paradigm

SCO:

Sound comparison oddball

FM:

Frequency-modulated

CSI:

Common stimulus-specific index

DII:

Double-identity index

DSI:

Double-spatial index

PSTHs:

Peri-stimulus time histograms

DD:

Double deviant

SID:

Single identity deviant

SSD:

Single spatial deviant

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Funding

All experiments were supported by the National Natural Science Foundation of China (31671081).

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Authors and Affiliations

  1. Department of Neurology of the Second Affiliated Hospital of Zhejiang University School of Medicine, Interdisciplinary Institute of Neuroscience and Technology of Qiushi Academy for Advanced Studies, College of Biomedical Engineering and Instrument Science, Zhejiang University, Room 210, Kexue Building, Huajiachi Campus, 258 Kaixuan Rd, Jianggan District, Hangzhou, 310029, Zhejiang, China

    Yu-Ying Zhai, Zhi-Hai Sun, Yu-Mei Gong, Yi Tang & Xiongjie Yu

  2. School of Information and Engineering, Hangzhou Dianzi University, Hangzhou, China

    Zhi-Hai Sun

Authors
  1. Yu-Ying Zhai
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  2. Zhi-Hai Sun
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  3. Yu-Mei Gong
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  4. Yi Tang
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  5. Xiongjie Yu
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Contributions

All authors contributed to the final version of the manuscript. XY designed the experiments and analyzed and interpreted the data; YYZ, ZHS, YMG, and YT collected and analyzed the data. All authors approved the final version of the manuscript.

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Correspondence to Xiongjie Yu.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving animals were in accordance with the ethical standards of the institution (ZJU20160246).

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Zhai, YY., Sun, ZH., Gong, YM. et al. Integrative stimulus-specific adaptation of the natural sounds in the auditory cortex of the awake rat. Brain Struct Funct 224, 1753–1766 (2019). https://doi.org/10.1007/s00429-019-01880-2

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  • DOI: https://doi.org/10.1007/s00429-019-01880-2

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