Abstract
Rightward prismatic adaptation (R-PA) was shown to alleviate not only visuo-spatial but also auditory symptoms in neglect. The neural mechanisms underlying the effect of R-PA have been previously investigated in visual tasks, demonstrating a shift of hemispheric dominance for visuo-spatial attention from the right to the left hemisphere both in normal subjects and in patients. We have investigated whether the same neural mechanisms underlie the supramodal effect of R-PA on auditory attention. Normal subjects underwent a brief session of R-PA, which was preceded and followed by an fMRI evaluation during which subjects detected targets within the left, central and right space in the auditory or visual modality. R-PA-related changes in activation patterns were found bilaterally in the inferior parietal lobule. In either modality, the representation of the left, central and right space increased in the left IPL, whereas the representation of the right space decreased in the right IPL. Thus, a brief exposure to R-PA modulated the representation of the auditory and visual space within the ventral attentional system. This shift in hemispheric dominance for auditory spatial attention offers a parsimonious explanation for the previously reported effects of R-PA on auditory symptoms in neglect.
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Abbreviations
- AG:
-
Angular gyrus
- PSC:
-
Percent signal changes
- fMRI:
-
Functional magnetic resonance imaging
- IPL:
-
Inferior parietal lobule
- R-PA:
-
Rightward prismatic adaptation
- L-PA:
-
Leftward prismatic adaptation
- SMG:
-
Supramarginal gyrus
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Acknowledgements
The work was supported by Grants from the Swiss National Science Foundation to S. Crottaz-Herbette (Marie-Heim-Vögtlin fellowship FNS PMPDP3_129028) and S. Clarke (FNS 320030-159708) and from the Biaggi Foundation to S. Crottaz-Herbette. The work was supported by the Centre d’Imagerie BioMédicale (CIBM) of the University of Lausanne (UNIL). We thank Jean-Baptiste Ledoux for his help in data acquisition.
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Tissieres, I., Fornari, E., Clarke, S. et al. Supramodal effect of rightward prismatic adaptation on spatial representations within the ventral attentional system. Brain Struct Funct 223, 1459–1471 (2018). https://doi.org/10.1007/s00429-017-1572-2
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DOI: https://doi.org/10.1007/s00429-017-1572-2