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Commonly preserved and species-specific gyral folding patterns across primate brains

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Abstract

Cortical folding pattern analysis is very important to understand brain organization and development. Since previous studies mostly focus on human brain cortex, the regularity and variability of cortical folding patterns across primate brains (macaques, chimpanzees and human) remain largely unknown. This paper presents a novel computational framework to identify common or unique gyral folding patterns in macaque, chimpanzee and human brains using magnetic resonance imaging (MRI) data. We quantitatively characterize gyral folding patterns via hinge numbers with cortical surfaces constructed from MRI data, and identify 6 common three-hinge gyral folds that exhibit consistent anatomical locations across these three species as well as 2 unique three hinges in macaque, 6 ones in chimpanzee and 14 ones in human. A novel morphology descriptor is then applied to classify three-hinge gyral folds, and the increasing complexity is identified among the species analyzed. This study may provide novel insights into the regularity and variability of the cerebral cortex from developmental perspective and may potentially facilitate novel neuroimage analyses such as cortical parcellation with correspondences across species in the future.

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Acknowledgements

T Liu was supported by the NIH Career Award EB006878 (2007–2012), NIH R01 HL087923-03S2 (2010–2012), NIH R01 DA033393 (2012–2017), NIH R01 AG-042599 (2013–2018), NSF CAREER Award IIS-1149260 (2012-2017), NSF CBET-1302089 (2013–2016), NSF BCS-1439051 (2014–2017) and NSF DBI-1564736 (2016–2019). T Zhang was supported by NSFC 31500798, the fundamental research funds for the central universities.

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  1. Kaiming Li

    Present address: West China Hospital of Sichuan University, Chengdu, China

Authors and Affiliations

  1. School of Automation, Northwestern Polytechnical University, Xi’an, China

    Xiao Li, Tuo Zhang, Xiang Yu, Xintao Hu, Junwei Han & Lei Guo

  2. Cortical Architecture Imaging and Discovery Lab, Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, GA, USA

    Hanbo Chen, Xi Jiang & Tianming Liu

  3. Department of Bioengineering, UC Riverside, Riverside, GA, USA

    Kaiming Li & Xiaoping Hu

  4. Marcus Autism Center, Emory University, Atlanta, GA, USA

    Longchuan Li

  5. Brain Decoding Research Center, Northwestern Polytechnical University, Xi’an, China

    Tuo Zhang

  6. College of Engineering, The University of Georgia, Athens, GA, USA

    Mir Jalil Razavi & Xianqiao Wang

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  1. Xiao Li
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Correspondence to Tianming Liu.

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X. Li, H. Chen and T. Zhang are co-first authors.

X. Hu and T. Liu are joint corresponding authors.

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Li, X., Chen, H., Zhang, T. et al. Commonly preserved and species-specific gyral folding patterns across primate brains. Brain Struct Funct 222, 2127–2141 (2017). https://doi.org/10.1007/s00429-016-1329-3

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