Abstract
The lateral hypothalamic area (LHA) has two major roles: arousal/waking and food intake controls. Here, it is shown that a premammillary part of the LHA is neurochemically and cytoarchitectonically distinct from the tuberal LHA in male rats. This part contains nuclear masses, namely the parasubthalamic nucleus and the calbindin nucleus, involved in pathways that predict its participation in the control of food intake. Analyzing c-Fos expression in experiments related to feeding behavior, this region responded specifically to the ingestion of palatable nutriments.
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Abbreviations
- AAA:
-
Anterior amygdalar area
- Ac:
-
Anterior commissure
- ACB:
-
Nucleus accumbens
- Aco:
-
Anterior commissure, olfactory limb
- ADP:
-
Anterodorsal preoptic nucleus
- AHN:
-
Anterior hypothalamic nucleus
- AId:
-
Agranular insular area, dorsal part
- AIp:
-
Agranular insular area, posterior part
- AIv:
-
Agranular insular area, ventral part
- AMB:
-
Nucleus ambiguus
- AMBd:
-
Nucleus ambiguus, dorsal division
- AMY:
-
Amygdala
- AP:
-
Area postrema
- AQ:
-
Cerebral aqueduct proper (sylvius)
- ARH:
-
Arcuate hypothalamic nucleus
- AVP:
-
Anteroventral preoptic nucleus
- B:
-
Barrington’s nucleus
- BLA:
-
Basolateral amygdalar nucleus
- BMA:
-
Basomedial amygdalar nucleus
- BMAa:
-
Basomedial amygdalar nucleus, anterior part
- BMAp:
-
Basomedial amygdalar nucleus, posterior part
- BST:
-
Bed nuclei stria terminalis
- cb:
-
Calbindin
- cbN:
-
Calbindin nucleus
- cc:
-
Corpus callosum
- ccg:
-
Corpus callosum, genu
- CEA:
-
Central amygdalar nucleus
- CEAc:
-
Central amygdalar nucleus, capsular part
- CEAm:
-
Central amygdalar nucleus, medial part
- CGRP:
-
Calcitonin gene-related peptide
- CLA:
-
Claustrum
- CLI:
-
Central linear nucleus raphe
- COAa:
-
Cortical amygdalar nucleus, anterior part
- CP:
-
Caudoputamen
- cpd:
-
Cerebral peduncle
- CS:
-
Superior central nucleus raphe
- CU:
-
Cuneate nucleus
- CUN:
-
Cuneiform nucleus
- dend.:
-
Dendrite
- DMH:
-
Dorsomedial hypothalamic nucleus
- DMX:
-
Dorsal motor nucleus vagus nerve
- DR:
-
Dorsal nucleus raphe
- DTN:
-
Dorsal tegmental nucleus
- EPd:
-
Endopiriform nucleus, dorsal part
- EW:
-
Edinger–Westphal nucleus
- FF:
-
Fields of Forel
- FG:
-
Fluorogold
- fr:
-
Fasciculus retroflexus
- FS:
-
Striatal fundus
- Fx:
-
Columns of the fornix
- GABA:
-
Gamma-aminobutyric acid
- GAD:
-
Glutamic acid decarboxylase
- GP:
-
Globus pallidus
- GR:
-
Gracile nucleus, principal part
- GRN:
-
Gigantocellular reticular nucleus
- GU:
-
Gustatory area
- Hcrt:
-
Hypocretin
- ic:
-
Internal capsule
- IC:
-
Inferior colliculus
- ICc:
-
Inferior colliculus, central nucleus
- IF:
-
Interfascicular nucleus raphe
- IG:
-
Induseum griseum
- III:
-
Oculomotor nucleus
- INC:
-
Interstitial nucleus of cajal
- INS:
-
Insular region
- IO:
-
Inferior olivary complex
- IPN:
-
Interpeduncular nucleus
- KF:
-
Kölliker–Fuse subnucleus (of PB)
- LA:
-
Lateral amygdalar nucleus
- Lat:
-
Lateral part of the LHA
- LC:
-
Locus ceruleus
- LDT:
-
Laterodorsal tegmental nucleus
- LGN:
-
Lateral geniculate nucleus
- LH:
-
Lateral habenula
- LHA:
-
Lateral hypothalamic area
- LHApm:
-
Lateral hypothalamic area, premammillary region
- LHAt:
-
Lateral hypothalamic area, tuberal region
- LM:
-
Lateral mammillary nucleus
- LPO:
-
Lateral preoptic area
- LRNm:
-
Lateral reticular nucleus, magnocellular part
- LSc:
-
Lateral septal nucleus, caudal (caudodorsal) part
- LSr:
-
Lateral septal nucleus, rostral (rostroventral) part
- LSv:
-
Lateral septal nucleus, ventral part
- MA:
-
Magnocellular nucleus
- MARN:
-
Magnocellular reticular nucleus
- MCH:
-
Melanin-concentrating hormone
- MDRN:
-
Medullary reticular nucleus
- ME:
-
Median eminence
- MEA:
-
Medial amygdalar nucleus
- MH:
-
Medial habenula
- MM:
-
Medial mammillary nucleus, body
- MPN:
-
Medial preoptic nucleus
- MPO:
-
Medial preoptic area
- MRNm:
-
Midbrain reticular nucleus, magnocellular part
- MS:
-
Medial septal nucleus
- mtt:
-
Mammillothalamic tract
- MV:
-
Medial vestibular nucleus
- NADPH:
-
Nicotinamide adenine dinucleotide phosphate
- ND:
-
Nucleus of Darkschewitsch
- NDB:
-
Diagonal band nucleus
- NG:
-
Nucleus gemini
- NLOT:
-
Nucleus of the lateral olfactory tract
- NPC:
-
Nucleus of the posterior commissure
- NR:
-
Nucleus of Roller
- NTB:
-
Nucleus of the trapezoid body
- NTS:
-
Nucleus of the solitary tract
- och:
-
Optic chiasm
- opt:
-
Optic tract
- OT:
-
Olfactory tubercle
- PAG:
-
Periaqueductal gray
- PARN:
-
Parvicellular reticular nucleus
- PB:
-
Parabrachial nucleus
- PBl:
-
Parabrachial nucleus, lateral division
- PBm:
-
Parabrachial nucleus, medial division
- PCG:
-
Pontine central gray
- PF:
-
Perifornical region of the LHA
- PG:
-
Pontine gray
- PGRNl:
-
Paragigantocellular reticular nucleus, lateral part
- PH:
-
Posterior hypothalamic nucleus
- PHA-L:
-
Phaseolus vulgaris leucoagglutinin
- PIR:
-
Piriform area
- pm:
-
Principal mammillary tract
- PMd:
-
Dorsal premammillary nucleus
- PMv:
-
Ventral premammillary nucleus
- POR:
-
Periolivary region
- PPN:
-
Pedunculopontine nucleus
- PRC:
-
Precommissural nucleus, periaqueductal gray
- PRNc:
-
Pontine reticular nucleus, caudal part
- PRNr:
-
Pontine reticular nucleus, rostral part
- PS:
-
Parastrial nucleus
- PSTN:
-
Parasubthalamic nucleus
- PSV:
-
Principal sensory nucleus of the trigeminal
- pTK1:
-
Preprotachykinin 1
- PV:
-
Parvalbumin
- PV1:
-
Parvalbumin nucleus
- PVH:
-
Paraventricular hypothalamic nucleus
- PVHdp:
-
Paraventricular hypothalamic nucleus, dorsal parvicellular part
- PVHmpv:
-
Paraventricular hypothalamic nucleus, medial parvicellular part, ventral zone
- PVHpml:
-
Paraventricular hypothalamic nucleus, posterior magnocellular part, lateral zone
- PVp:
-
Periventricular hypothalamic nucleus, posterior part
- PVT:
-
Paraventricular thalamic nucleus
- RE:
-
Nucleus reuniens
- RL:
-
Rostral linear nucleus raphe
- RM:
-
Nucleus raphe magnus
- RN:
-
Red nucleus
- SC:
-
Superior colliculus
- SCH:
-
Suprachiasmatic nucleus
- SCi:
-
Superior colliculus, intermediate layer
- SF:
-
Septofimbrial nucleus
- SH:
-
Septohippocampal nucleus
- SI:
-
Substantia innominata
- SLD:
-
Sublaterodorsal nucleus
- sm:
-
Stria medullaris
- SNc:
-
Substantia nigra, compact part
- SNr:
-
Substantia nigra, reticular part
- SON:
-
Supraoptic nucleus
- SP:
-
Substance P
- SPVC:
-
Spinal nucleus of the trigeminal, caudal part
- SPVI:
-
Spinal nucleus of the trigeminal, interpolar part
- STN:
-
Subthalamic nucleus
- SUM:
-
Supramammillary nucleus
- TH:
-
Tyrosine hydroxylase
- TMd:
-
Tuberomammillary nucleus, dorsal part
- TMv:
-
Tuberomammillary nucleus, ventral part
- TRN:
-
Tegmental reticular nucleus, pontine gray
- TTd2:
-
Tenia tecta, dorsal part, layers 2
- TU:
-
Tuberal nucleus
- TUte:
-
Tuberal nucleus, terete subnucleus
- V3:
-
Third ventricle
- V3m:
-
Third ventricle, mammillary recess
- V4:
-
Fourth ventricle proper
- VIS:
-
Visual area
- vlt:
-
Ventrolateral hypothalamic tract
- Vma:
-
Motor nucleus of the trigeminal, magnocellular part
- VMH:
-
Ventromedial hypothalamic nucleus
- VPMpc:
-
Ventral posteromedial nucleus thalamus, parvicellular part
- VTA:
-
Ventral tegmental area
- VTN:
-
Ventral tegmental nucleus
- XII:
-
Hypoglossal nucleus
- ZI:
-
Zona incerta
- ZIda:
-
Zona incerta, dopaminergic group
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Acknowledgments
This work was supported by funding from the French Ministère de la Recherche et de la Technologie (EA 3922) and from the Région de Franche-Comté. The authors thank C. Houdayer, G. Franchi-Bernard, F. Poncet and A. Mariot for technical assistances. We thank G. Sanchez-Watts, D. M. Simmons, R. H. Thompson, G. D. Petrovich, E. A. Markakis, A. B. Kelly and L. W. Swanson for helping to prepare the in situ hybridization material and A. Tobin for the GAD65 and GAD67 probes.
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The authors declare that they have no conflict of interest.
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Chometton, S., Pedron, S., Peterschmitt, Y. et al. A premammillary lateral hypothalamic nuclear complex responds to hedonic but not aversive tastes in the male rat. Brain Struct Funct 221, 2183–2208 (2016). https://doi.org/10.1007/s00429-015-1038-3
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DOI: https://doi.org/10.1007/s00429-015-1038-3