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Intrahemispheric cortico-cortical connections of the human auditory cortex

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Abstract

The human auditory cortex comprises the supratemporal plane and large parts of the temporal and parietal convexities. We have investigated the relevant intrahemispheric cortico-cortical connections using in vivo DSI tractography combined with landmark-based registration, automatic cortical parcellation and whole-brain structural connection matrices in 20 right-handed male subjects. On the supratemporal plane, the pattern of connectivity was related to the architectonically defined early-stage auditory areas. It revealed a three-tier architecture characterized by a cascade of connections from the primary auditory cortex to six adjacent non-primary areas and from there to the superior temporal gyrus. Graph theory-driven analysis confirmed the cascade-like connectivity pattern and demonstrated a strong degree of segregation and hierarchy within early-stage auditory areas. Putative higher-order areas on the temporal and parietal convexities had more widely spread local connectivity and long-range connections with the prefrontal cortex; analysis of optimal community structure revealed five distinct modules in each hemisphere. The pattern of temporo-parieto-frontal connectivity was partially asymmetrical. In conclusion, the human early-stage auditory cortical connectivity, as revealed by in vivo DSI tractography, has strong similarities with that of non-human primates. The modular architecture and hemispheric asymmetry in higher-order regions is compatible with segregated processing streams and lateralization of cognitive functions.

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Abbreviations

AA:

Anterior auditory area

ALA:

Anterolateral auditory area

LA:

Lateral auditory area

LP:

Lateroposterior auditory area

MA:

Medial auditory area

PA:

Posterior auditory area

PAC:

Primary auditory cortex

STA:

Superior temporal auditory area

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Acknowledgments

This work has been supported by the Swiss National Science Foundation Grants 3200030-124897 and 320030B-141177 to S. Clarke. PH was supported by Leenaards Foundation.

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Authors and Affiliations

  1. Service de Neuropsychologie et de Neuroréhabilitation, CHUV, Université de Lausanne, Lausanne, Switzerland

    Leila Cammoun & Stephanie Clarke

  2. Signal Processing Laboratory, EPFL, Lausanne, Switzerland

    Jean Philippe Thiran & Alessandra Griffa

  3. Service de Radiodiagnostic et Radiologie Interventionnelle, CHUV, Université de Lausanne, Lausanne, Switzerland

    Reto Meuli & Patric Hagmann

Authors
  1. Leila Cammoun
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  2. Jean Philippe Thiran
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  3. Alessandra Griffa
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  4. Reto Meuli
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  5. Patric Hagmann
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  6. Stephanie Clarke
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Correspondence to Leila Cammoun or Stephanie Clarke.

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Cammoun, L., Thiran, J.P., Griffa, A. et al. Intrahemispheric cortico-cortical connections of the human auditory cortex. Brain Struct Funct 220, 3537–3553 (2015). https://doi.org/10.1007/s00429-014-0872-z

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  • DOI: https://doi.org/10.1007/s00429-014-0872-z

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