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Predictive value of tumor budding in head and neck squamous cell carcinoma: an update

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Abstract 

Head and neck squamous cell carcinoma forms an anatomically and functionally complex group of malignancies. The significant local aggressiveness and frequent regional relapses motivate ongoing research to identify more reliable and sensitive prognostic and predictive biomarkers. One emerging area of cancer biology is the evaluation of tumor budding at the advancing invasive front of various types of epithelial cancers. Recent studies suggest that tumor budding is a relatively common phenomenon in cancer progression and that it may have important prognostic implications for patients due to its potential to provide valuable insights into the biology and clinical behavior of head and neck cancer. In this review, we aim to provide information about tumor budding in head and neck squamous cell carcinoma. Thus, we hope to shed light on the complex biology of these malignancies, as well as aiding diagnostic, classification, and better characterization and thereby, looking for new avenues for improving patient outcomes.

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Authors and Affiliations

  1. Department of Otorhinolaryngology, Osakidetza, Donostia University Hospital, Biodonostia Research Institute, 20014, San Sebastian, Spain

    Carlos M. Chiesa-Estomba

  2. Otorhinolaryngology Department, Faculty of Medicine, Deusto University, Bilbao, Spain

    Carlos M. Chiesa-Estomba

  3. Head and Neck Pathology Consultations, Woodland Hills, CA, 91364, USA

    Lester Thompson

  4. Institut Für Pathologie, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany

    Abbas Agaimy

  5. Institute of Pathology, Faculty of Medicine, University of Ljubljana, 1000, Ljubljana, Slovenia

    Nina Zidar

  6. Department of Anatomical Pathology, University of Calgary, Calgary, AB, Canada

    Roderick H. W. Simpson

  7. Department of Translational Research and of New Technologies in Medicine and Surgery, University of Pisa, 56126, Pisa, Italy

    Alessandro Franchi

  8. Department of Otolaryngology, Hospital Universitario Central de Asturias, University of Oviedo, ISPA, IUOPA, CIBERONC, Oviedo, Spain

    Juan P. Rodrigo

  9. Department of Otorhinolaryngology-Head and Neck Surgery, Research Program in Systems Oncology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland

    Antti A. Mäkitie

  10. Research Program in Systems Oncology, Faculty of Medicine, University of Helsinki, Helsinki, Finland

    Alhadi Almangush

  11. Department of Pathology, University of Helsinki, Helsinki, Finland

    Alhadi Almangush

  12. Institute of Biomedicine, Pathology, University of Turku, Turku, Finland

    Ilmo Leivo

  13. Coordinator of the International Head and Neck, Scientific Group, Padua, Italy

    Alfio Ferlito

Authors
  1. Carlos M. Chiesa-Estomba
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  2. Lester Thompson
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  3. Abbas Agaimy
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  4. Nina Zidar
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  6. Alessandro Franchi
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  7. Juan P. Rodrigo
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  8. Antti A. Mäkitie
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  9. Alhadi Almangush
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Contributions

Carlos Chiesa-Estomba, Antti A. Mäkitie, and Alhadi Almangush made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data; or the creation of new software used in the work. Carlos Chiesa-Estomba, Lester Thompson, Abbas Agaimy, Nina Zidar, Roderick HW Simpson, Juan P. Rodrigo, Antti A. Mäkitie, and Alhadi Almangush drafted the work or revised it critically for important intellectual content. Carlos Chiesa-Estomba, Lester Thompson, Abbas Agaimy, Nina Zidar, Roderick HW Simpson, Alessandro Franchi, Juan P. Rodrigo, Ilmo Leivo, and Alfio Ferlito approved the version to be published. Abbas Agaimy, Ilmo Leivo, and Alfio Ferlito agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Carlos M. Chiesa-Estomba.

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Chiesa-Estomba, C.M., Thompson, L., Agaimy, A. et al. Predictive value of tumor budding in head and neck squamous cell carcinoma: an update. Virchows Arch 483, 441–449 (2023). https://doi.org/10.1007/s00428-023-03630-6

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  • DOI: https://doi.org/10.1007/s00428-023-03630-6

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