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The OLGA-OLGIM staging and the interobserver agreement for gastritis and preneoplastic lesion screening: a cross-sectional study

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Abstract

Stomach cancer (SC) incidence and mortality are relevant public health issues worldwide. In Colombia, screening for preneoplastic lesions (PNL) and the presence of H. pylori is not routinely performed. Therefore, the aim of this study was to evaluate OLGA-OLGIM staging and the interobserver agreement in gastritis and preneoplastic lesions in patients with gastroduodenal symptoms from Colombia. A cross-sectional study was conducted in 272 patients with gastroduodenal symptoms. Gastric biopsies were taken following the Updated Sydney System with the OLGA-OLGIM classification, and the results were evaluated by two pathologists. Chronic gastritis and PNL were reported in 76% and 24% of the patients, respectively. Furthermore, 25% of the patients with PNL displayed gastric atrophy (GA) and 75% intestinal metaplasia (IM). Agreement in the histopathological reading for IM was good, whereas for OLGA was variable, and for the H. pylori quantity was poor. OLGA-OLGIM stages 0-II were the most frequent (96%), while stage III (4%) and SC (4%) were the least frequent. Age and coffee consumption were associated with a higher prevalence of PNL. This work determined that 4% of the population is at high risk of developing SC and would benefit from follow-up studies. Reinforcement of training programs to improve the agreement in histopathology readings is required.

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Fig. 1
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Courtesy from José Armando Justinico Castro MD, Pathologist

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Data availability

The data are available without any patient identification upon request, emailing beatriz.salazar@udea.edu.co (corresponding author).

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Acknowledgements

The authors would like to thank to the Infectious Disease Group, Department of Microbiology, Pontificia Universidad Javeriana and Cancer Biology Research Group National Cancer Institute, for the donation of the reference strain H. pylori. Thanks to Dr. Zulma Rueda Vallejo for the constructive comments.

Funding

This study was funded by Comité Para el Desarrollo de la Investigación (CODI) Universidad de Antioquia, grant number 2014–1062 and National Doctoral Scholar by Ministerio de Ciencia, Tecnología e Innovación (Minciencias), grant number 617–2013.

Author information

Authors and Affiliations

  1. Bacteria & Cancer Group, Department of Microbiology, School of Medicine, University of Antioquia, Medellín, Colombia

    Beatriz E. Salazar, Tania Pérez-Cala, Sara Isabel Gomez-Villegas, Laura Cardona-Zapata, Sebastián Pazos-Bastidas, Alejandra Cardona-Estepa, Diego Enrique Vélez-Gómez, Juan Carlos Benítez-Guerra, Miguel Ignacio Roldán-Pérez & Alonso Martínez

  2. Department of Pathology, School of Medicine, University of Antioquia, Medellín, Colombia

    José Armando Justinico-Castro, Andrés Bernal-Cobo, Harold Adrián Dávila-Giraldo & Miguel Ignacio Roldán-Pérez

  3. Promedan IPS, Medellín, Colombia

    Juan Carlos Benítez-Guerra

  4. IPS Universitaria, University of Antioquia, Medellín, Colombia

    Joaquín Tiberio Valencia-Cárdenas

  5. Somer Clinic, Rionegro, Colombia

    Edgar de Jesús Ospina

  6. Cancer Institute, Las Americas Clinic, Medellín, Colombia

    Rodrigo Castaño-Llano

  7. Cancer Biology Research Group, National Cancer Institute, Bogotá, Colombia

    María Mercedes Bravo

  8. Internal Medicine Infectious Disease Section, University of Antioquia, Medellín, Colombia

    Juan Carlos Cataño-Correa

  9. Department of Integrative Oncology and Department of Pediatrics, Stanley S. Scott Cancer Center, Louisiana State University Health Sciences Center, New Orleans, LA, USA

    Jovanny Zabaleta

  10. Infectious Disease Group, Department of Microbiology, Pontificia Universidad Javeriana, Bogotá, Colombia

    Alba Alicia Trespalacios-Rangel

  11. Cytology and Pathology Unit, Las Vegas Clinic, Medellín, Colombia

    Ana María Cock-Botero

Authors
  1. Beatriz E. Salazar
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  2. Tania Pérez-Cala
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  3. Sara Isabel Gomez-Villegas
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  4. Laura Cardona-Zapata
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Contributions

Funds and resources: Tania Pérez-Cala, Alonso Martínez, Beatriz E. Salazar, Ana María Cock Botero.

Project administration: Alonso Martínez, Beatriz E. Salazar.

Project supervision: Alonso Martínez, Beatriz E. Salazar.

Academic advising: Alonso Martínez, Alba Alicia Trespalacios-Rangel, Maria Mercedes Bravo, Juan Carlos Cataño-Correa, Jovanny Zabaleta.

Methodology design: Alonso Martínez, Tania Pérez-Cala, Beatriz E. Salazar, Alba Alicia Trespalacios.

Data collection: Beatriz E. Salazar, Tania Pérez-Cala, Sara Gómez Villegas, Laura Cardona-Zapata, Sebastián Pazos-Bastidas, Juan Carlos Benítez Guerra, Joaquin Tiberio Valencia Cárdenas, Edgar de Jesús Ospina, Rodrigo Castaño Llano.

Laboratory tests: José Justinico Castro, Andrés Felipe Bernal Cobo, Harold Dávila, Miguel Ignacio Roldan, Ana María Cock Botero, Beatriz E. Salazar.

Database management: Alejandra Cardona-Estepa, Diego E. Vélez, Alba Alicia Trespalacios-Rangel, Maria Mercedes Bravo, Juan Carlos Cataño-Correa, Jovanny Zabaleta, Beatriz E. Salazar.

Statistical data analysis: Diego E. Vélez, Beatriz E. Salazar.

Manuscript writing: all authors.

Corresponding author

Correspondence to Beatriz E. Salazar.

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Ethics statement

The consent and survey were approved by the Bioethics Committee of the Faculty of Medicine of the University of Antioquia – Colombia (ethics approval number: 013–2016). Each participant signed the consent form and approved the publication of the results.

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The authors declare no competing interests.

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Salazar, B.E., Pérez-Cala, T., Gomez-Villegas, S.I. et al. The OLGA-OLGIM staging and the interobserver agreement for gastritis and preneoplastic lesion screening: a cross-sectional study. Virchows Arch 480, 759–769 (2022). https://doi.org/10.1007/s00428-022-03286-8

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