Skip to main content

Advertisement

SpringerLink
Log in

Differential CD133 expression distinguishes malignant from benign papillary lesions of the breast

  • Original Article
  • Published:
Virchows Archiv Aims and scope Submit manuscript

Abstract

Malignant papillary lesions are, in contrast to their benign counterpart, rare malignant tumors in the breast. To differentiate between benign or atypical and malignant papillary lesions can be difficult, especially in core biopsy specimens. In the present study, excisional or more extensive surgical specimens of 33 papillary carcinomas, 2 micropapillary carcinomas, and 17 atypical papillomas of the breast were reviewed and classified according to the latest WHO classification. Thirty-three intraductal papillomas and 49 invasive carcinomas, no special type (NST), were included in the study for comparison. CD133 expression in papillary carcinomas was significantly lower than that in benign and atypical papillomas (p < 0.001). CD133 expression in invasive carcinoma NST was also significantly higher than that in papillary carcinomas. Our data suggests that absence of expression of CD133 can be a useful marker in the differential diagnosis between malignant papillary lesions and their benign or atypical mimics. The characteristic loss of CD133 expression in papillary carcinomas of the breast also indicates that these lesions are distinct from other types of breast cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Lakhani SR, Ellis IO, Schnitt SJ, Tan PH, van de Vijver MJ (2012) WHO classification of tumours of the breast, 4th, edth edn. IARC, Lyon

    Google Scholar 

  2. Louwman MW, Vriezen M, van Beek MW, Nolthenius-Puylaert MC, van der Sangen MJ, Roumen RM, Kiemeney LA, Coebergh JW (2007) Uncommon breast tumors in perspective: incidence, treatment and survival in the Netherlands. Int J Cancer 121:127–135

    Article  CAS  PubMed  Google Scholar 

  3. McCulloch GL, Evans AJ, Yeoman L, Wilson AR, Pinder SE, Ellis IO, Elston CW (1997) Radiological features of papillary carcinoma of the breast. Clin Radiol 52:865–868

    Article  CAS  PubMed  Google Scholar 

  4. Grabowski J, Salzstein SL, Sadler GR, Blair S (2008) Intracystic papillary carcinoma: a review of 917 cases. Cancer 113:916–920

    Article  PubMed Central  PubMed  Google Scholar 

  5. Battula VL, Shi Y, Evans KW, Wang RY, Spaeth EL, Jacamo RO, Guerra R, Sahin AA, Marini FC, Hortobagyi G, Mani SA, Andreeff M (2012) Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest 122:2066–2078

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  6. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, Visvader J, Weissman IL, Wahl GM (2006) Cancer stem cells—perspectives on current status and future directions: AACR workshop on cancer stem cells. Cancer Res 66:9339–9344

    Article  CAS  PubMed  Google Scholar 

  7. Takahashi RU, Takeshita F, Fujiwara T, Ono M, Ochiya T (2011) Cancer stem cells in breast cancer. Cancers (Basel) 3:1311–1328

    Article  CAS  Google Scholar 

  8. Iqbal J, Chong PY, Tan PH (2013) Breast cancer stem cells: an update. J Clin Pathol 66:485–490

    Article  CAS  PubMed  Google Scholar 

  9. Bao S, Wu Q, McLendon RE, Hao Y, Shi Q, Hjelmeland AB, Dewhirst MW, Bigner DD, Rich JN (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 444:756–760

    Article  CAS  PubMed  Google Scholar 

  10. Hermann PC, Huber SL, Herrler T, Aicher A, Ellwart JW, Guba M, Bruns CJ, Heeschen C (2007) Distinct populations of cancer stem cells determine tumor growth and metastatic activity in human pancreatic cancer. Cell Stem Cell 1:313–323

    Article  CAS  PubMed  Google Scholar 

  11. Visvader JE, Lindeman GJ (2008) Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Nat Rev Cancer 8:755–768

    Article  CAS  PubMed  Google Scholar 

  12. Zhao P, Lu Y, Jiang X, Li X (2011) Clinicopathological significance and prognostic value of CD133 expression in triple-negative breast carcinoma. Cancer Sci 102:1107–1111

    Article  CAS  PubMed  Google Scholar 

  13. Nadal R, Ortega FG, Salido M, Lorente JA, Rodriguez-Rivera M, Delgado-Rodriguez M, Macia M, Fernandez A, Corominas JM, Garcia-Puche JL, Sanchez-Rovira P, Sole F, Serrano MJ (2013) CD133 expression in circulating tumor cells from breast cancer patients: potential role in resistance to chemotherapy. Int J Cancer 133:2398–2407

    Article  CAS  PubMed  Google Scholar 

  14. Pathmanathan N, Albertini AF, Provan PJ, Milliken JS, Salisbury EL, Bilous AM, Byth K, Balleine RL (2010) Diagnostic evaluation of papillary lesions of the breast on core biopsy. Mod Pathol 23:1021–1028

    Article  PubMed  Google Scholar 

  15. Collins LC, Schnitt SJ (2008) Papillary lesions of the breast: selected diagnostic and management issues. Histopathology 52:20–29

    Article  CAS  PubMed  Google Scholar 

  16. Pal SK, Lau SK, Kruper L, Nwoye U, Garberoglio C, Gupta RK, Paz B, Vora L, Guzman E, Artinyan A, Somlo G (2010) Papillary carcinoma of the breast: an overview. Breast Cancer Res Treat 122:637–645

    Article  PubMed Central  PubMed  Google Scholar 

  17. Tokiniwa H, Horiguchi J, Takata D, Kikuchi M, Rokutanda N, Nagaoka R, Sato A, Odawara H, Tozuka K, Oyama T, Takeyoshi I (2011) Papillary lesions of the breast diagnosed using core needle biopsies. Exp Ther Med 2:1069–1072

    PubMed Central  PubMed  Google Scholar 

  18. Tse GM, Tan PH, Moriya T (2009) The role of immunohistochemistry in the differential diagnosis of papillary lesions of the breast. J Clin Pathol 62:407–413

    Article  CAS  PubMed  Google Scholar 

  19. Di Cristofano C, Mrad K, Zavaglia K, Bertacca G, Aretini P, Cipollini G, Bevilacqua G, Ben Romdhane K, Cavazzana A (2005) Papillary lesions of the breast: a molecular progression? Breast Cancer Res Treat 90:71–76

    Article  PubMed  Google Scholar 

  20. Lininger RA, Park WS, Man YG, Pham T, MacGrogan G, Zhuang Z, Tavassoli FA (1998) LOH at 16p13 is a novel chromosomal alteration detected in benign and malignant microdissected papillary neoplasms of the breast. Hum Pathol 29:1113–1118

    Article  CAS  PubMed  Google Scholar 

  21. Troxell ML, Levine J, Beadling C, Warrick A, Dunlap J, Presnell A, Patterson J, Shukla A, Olson NR, Heinrich MC, Corless CL (2010) High prevalence of PIK3CA/AKT pathway mutations in papillary neoplasms of the breast. Mod Pathol 23:27–37

    Article  CAS  PubMed  Google Scholar 

  22. Aomatsu N, Yashiro M, Kashiwagi S, Takashima T, Ishikawa T, Ohsawa M, Wakasa K, Hirakawa K (2012) CD133 is a useful surrogate marker for predicting chemosensitivity to neoadjuvant chemotherapy in breast cancer. PLoS One 7:e45865

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Ohtsubo I, Ajiki T, Hori Y, Murakami S, Shimizu K, Itoh T, Shimizu M, Fukumoto T, Ku Y (2012) Distinctive expression of CD133 between intraductal papillary neoplasms of the bile duct and bile duct adenocarcinomas. Hepatol Res 42:574–582

    Article  PubMed  Google Scholar 

  24. Shimizu K, Itoh T, Shimizu M, Ku Y, Hori Y (2009) CD133 expression pattern distinguishes intraductal papillary mucinous neoplasms from ductal adenocarcinomas of the pancreas. Pancreas 38:e207–e214

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgments

This study was supported by a grant from the Kaohsiung Medical University Hospital (KMUH102-2M64).

Conflict of interest

We declare that we have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Pathology, Kaohsiung Medical University Hospital, No. 100, Tzyou 1st Road, Kaohsiung, 807, Taiwan

    Chih-Hung Lin, Chia-Hsing Liu, Chien-Hui Wen, Pei-Ling Ko & Chee-Yin Chai

  2. Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan

    Chih-Hung Lin & Chee-Yin Chai

  3. Department of Pathology, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan

    Chee-Yin Chai

Authors
  1. Chih-Hung Lin
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chia-Hsing Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Chien-Hui Wen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Pei-Ling Ko
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Chee-Yin Chai
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chee-Yin Chai.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lin, CH., Liu, CH., Wen, CH. et al. Differential CD133 expression distinguishes malignant from benign papillary lesions of the breast. Virchows Arch 466, 177–184 (2015). https://doi.org/10.1007/s00428-014-1695-2

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00428-014-1695-2

Keywords

Search

Navigation