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Peripheral arterial tone during active standing

  • Organ physiology
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Abstract

Active standing test is clinically used to detect inadequate sympathetic nervous system response to the orthostasis. Peripheral arterial tone (PAT) is a recently developed technology whereby sympathetic activity can be measured through monitoring the digit arterial pulsatile volume. We aimed to determine the response of PAT to the orthostasis. The PAT and short-time frequency domain heart rate variability (HRV) were simultaneously measured during a 5.5-min active standing test in volunteers. The endpoints were changes in the PAT and ratio of low frequency to high frequency (LH/HF) before and after the postural changes: sitting→standing→sitting again. The blood pressure (BP) was constant throughout the test while the heart rate increased during standing in 54 participants. The natural logarithm of the mean LF/HF increased in the standing position (sitting, standing, and sitting again, mean±standard deviation, 1.3±1.04, 1.73±1.15, and 1.51±0.94; p=0.006), and the natural logarithm of its peak value was the highest also while standing (2.58±1.19, 3.08±1.2, and 2.85±1.05; p=0.007). The mean PAT (487.5±277.7, 314.5±180.4, and 458.1±244.3; p <0.001) and its nadir value (341.8±204.8, 189.4±119.2, and 264.3±157.6; p <0.001) declined during standing, and reascended after sitting again. The percent change before and after the standing in mean PAT was not correlated with that of the mean LF/HF. In conclusion, the PAT changed independently of and inversely with the LF/HF during the orthostatic test while the BP remained constant, possibly reflecting peripheral vasocontraction needed for the BP homeostasis.

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Authors and Affiliations

  1. Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences, Hiroshima, Japan

    Sho Okamura, Takehito Tokuyama, Yosaku Okubo, Yoshihiro Ikeuchi, Shunsuke Miyauchi & Yukiko Nakano

  2. Department of Cardiology, Cardiovascular Center, Onomichi General Hospital, 1-10-23 Hirahara, Onomichi, 722-8508, Japan

    Akinori Sairaku

  3. Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan

    Yukihito Higashi

Authors
  1. Sho Okamura
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  2. Akinori Sairaku
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  3. Takehito Tokuyama
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  4. Yosaku Okubo
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  5. Yoshihiro Ikeuchi
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  6. Shunsuke Miyauchi
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  7. Yukihito Higashi
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  8. Yukiko Nakano
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Correspondence to Akinori Sairaku.

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Supplementary Information

Supplementary Figure A

summary of the main findings. The means and standard deviations, and the means and standard errors are presented in the upper and lower panels, respectively. Abbreviations are the same as in Figures 3 and 6 (PNG 13962 kb)

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Okamura, S., Sairaku, A., Tokuyama, T. et al. Peripheral arterial tone during active standing. Pflugers Arch - Eur J Physiol 473, 1939–1946 (2021). https://doi.org/10.1007/s00424-021-02632-0

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  • DOI: https://doi.org/10.1007/s00424-021-02632-0

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