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Impact of tumor location on lymph node metastasis in T1 colorectal cancer

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Abstract

Purpose

Data evaluating the risk of lymph node metastasis depending upon the location of the primary tumor are limited in patients with T1 colorectal cancer. We aimed to evaluate the impact of tumor location on lymph node metastasis in T1 colorectal cancer.

Methods

Patients who underwent an oncologic resection with curative intent for T1 adenocarcinoma of the colon and rectum between January 1997 and October 2014 were assessed. Exclusion criteria were distant organ metastases, previous or concurrent cancer, past history of surgical or medical cancer treatment, preoperative chemoradiation, and patients with inflammatory bowel disease or polyposis syndromes.

Results

Out of 232 (56 % male) patients fulfilling the study criteria, 24 (10 %) had lymph node metastasis. Age (65 vs 61 years, p = 0.1), gender (55 vs 63 % male, p = 0.5), tumor size (2 vs 2 cm, p = 0.49), and lymphovascular invasion (5 vs 8 %, p = 0.46) were not associated with lymph node metastasis. While there was no statistical significance (p = 0.2), lymph node positivity was higher in rectal cancer (14 %, n = 11/79) compared to colon cancer (9 %, n = 13/153).

Conclusions

Although it was not statistically significant, lymph node positivity varies based on tumor location of T1 colorectal adenocarcinoma regardless of fundamental tumor characteristics including size, differentiation, and lymphovascular invasion.

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Acknowledgments

The study was a poster presentation at the American Society of Colon and Rectal Surgeons Annual Meeting, May 30–June 3, 2015, Boston, MA. This study was supported by the Ed and Joey Story Endowed Chair in Colorectal Surgery. Erman Aytac is an assistant professor of surgery at the Acibadem University School of Medicine in Istanbul, Turkey.

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Authors and Affiliations

  1. Department of Colorectal Surgery, Digestive Disease Institute, Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH, 44195, USA

    Erman Aytac, Emre Gorgun, Meagan M Costedio, Luca Stocchi, Feza H Remzi & Hermann Kessler

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  1. Erman Aytac
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  2. Emre Gorgun
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  3. Meagan M Costedio
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  4. Luca Stocchi
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  5. Feza H Remzi
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  6. Hermann Kessler
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Correspondence to Hermann Kessler.

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The authors declare that they have no conflict of interest.

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Aytac, E., Gorgun, E., Costedio, M.M. et al. Impact of tumor location on lymph node metastasis in T1 colorectal cancer. Langenbecks Arch Surg 401, 627–632 (2016). https://doi.org/10.1007/s00423-016-1452-x

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  • DOI: https://doi.org/10.1007/s00423-016-1452-x

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