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Surgical strategy for primary hyperparathyreoidism with thyroid hemiagenesis

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Abstract

Background

Thyroid hemiagenesis is a rare congenital anomaly, and still more rarely associated with primary hyperparathyroidism (pHPT). Due to the embryologic pathways of the thyroid and parathyroid glands, it remains unclear whether or not thyroid hemiagenesis may be linked to ipsilateral parathyroid agenesis, and consequently, surgical strategy for thyroid hemiagenesis associated pHPT (THAP) does not only depend on preoperative localization but also on the thyroid anomaly.

Methods

Including the present case report, a total of nine cases with THAP retrieved from the literature were reviewed. Seven of nine cases had thyroid hemiagenesis on the left side, three out of nine showed a parathyroid adenoma on the contralateral side to the thyroid hemiagenesis.

Conclusions

Based on these cases, it can be concluded that the embryologic pathways of the thyroid and parathyroid glands are different, and in cases of THAP, parathyroid exploration should follow standard recommendations for pHPT surgery.

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Authors and Affiliations

  1. Division of General, Surgery Ospedale di Circolo, University of Insubria, Via Guicciardini, 21100, Varese, Italy

    Cesare Carlo Ferrari & Gianlorenzo Dionigi

  2. Department of General, Visceral, and Vascular Surgery, University Hospital, University of Halle-Wittenberg, Ernst-Grube-Strasse 40, 06097, Halle/Saale, Germany

    Kerstin Lorenz & Henning Dralle

  3. Endocrine Surgery Research Center, Department of Surgical Sciences, University of Insubria (Varese-Como), Via Guicciardini, 21100, Varese, Italy

    Cesare Carlo Ferrari & Gianlorenzo Dionigi

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  1. Cesare Carlo Ferrari
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  2. Kerstin Lorenz
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Correspondence to Kerstin Lorenz.

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Ferrari, C.C., Lorenz, K., Dionigi, G. et al. Surgical strategy for primary hyperparathyreoidism with thyroid hemiagenesis. Langenbecks Arch Surg 399, 1077–1081 (2014). https://doi.org/10.1007/s00423-014-1228-0

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  • DOI: https://doi.org/10.1007/s00423-014-1228-0

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