Abstract
Purpose
Acute resistance exercise decreases endothelial function in sedentary individuals but not in strength-trained (ST) individuals. However, the underlying mechanism(s) of vascular protection in ST individuals remains unclear. Herein, we compared catecholamines, endothelin-1 (ET-1), and nitric oxide (NOx) releases after acute resistance exercise between sedentary and ST individuals.
Methods
The untrained (UT) group comprised 12 male individuals with no regular training, while the ST group comprised 12 male individuals. Participants performed a session of resistance exercise, which consisted of 3 sets of 10 repetitions at 75% of one repetition maximum. Heart rate (HR) and blood pressure were measured during resistance exercise. Brachial artery flow-mediated dilation (FMD), blood pressure, HR, and blood collection were undertaken before and 10, 30, and 60 min after the resistance exercise.
Results
No significant difference was found in baseline brachial artery FMD between the groups (P > 0.05). Brachial artery FMD was significantly reduced in the UT group (P < 0.05) but it was prevented in the ST group after the resistance exercise. Significant differences were found at 10, 30, and 60 min after the resistance exercise in brachial artery ΔFMD from baseline between groups (P < 0.05). Blood pressure, HR, plasma epinephrine, norepinephrine, dopamine, serum endothelin-1, and plasma NOx responses did not differ between groups throughout the experimental period.
Conclusion
In conclusion, preserved endothelial function in response to acute resistance exercise in ST male individuals is independent of catecholamines, ET-1, and NOx responses.
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Data availability
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Abbreviations
- ET-1:
-
Endothelin-1
- NO:
-
Nitric oxide
- ST:
-
Strength-trained
- FMD:
-
Flow-mediated dilation
- UT:
-
Untrained group
- 1RM:
-
One repetition maximum
- HR:
-
Heart rate
- AUC:
-
Area under the curve
- NOx:
-
Nitrate/Nitrite
- ANOVA:
-
Analysis of variance
- ANCOVA:
-
Analysis of covariance
- SD:
-
Standard deviation
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Acknowledgements
The authors appreciate the time and effort put in by all volunteer participants. The authors are grateful to Ayaka Mori and Sumika Kubo for their support in terms of data collection and blood analysis. This work was supported by The Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research [grant number 21K17553 (to T.M.)].
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Japan Society for the Promotion of Science, 21K17553, Takuma Morishima.
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T.M. conceptualized and designed the study; T.M. and N.K. performed experiments; T.M. analyzed data; T.M. and N.K. interpreted the results of experiments; T.M. prepared figures and tables. T.M. drafted the manuscript; T.M. and N.K. edited and revised the manuscript; T.M. and N.K. approved the final version of the manuscript.
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Morishima, T., Kasai, N. Circulating catecholamines, endothelin-1, and nitric oxide releases do not explain the preserved FMD following acute resistance exercise in strength-trained men. Eur J Appl Physiol (2024). https://doi.org/10.1007/s00421-024-05468-5
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DOI: https://doi.org/10.1007/s00421-024-05468-5