Association between $$\dot{\text{V}}$$ O2 kinetics and $$\dot{\text{V}}$$ O2max in groups differing in fitness status

Inglis, Erin Calaine; Iannetta, Danilo; Murias, Juan M.

doi:10.1007/s00421-021-04623-6

Association between $\dot{\text{V}}$O₂ kinetics and $\dot{\text{V}}$O_2max in groups differing in fitness status

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Published: 17 March 2021

Volume 121, pages 1921–1931, (2021)
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Abstract

Purpose

This study evaluated (i) the relationship between oxygen uptake ($\dot{\text{V}}$O₂) kinetics and maximal $\dot{\text{V}}$O₂ ($\dot{\text{V}}$O_2max) within groups differing in fitness status, and (ii) the adjustment of $\dot{\text{V}}$O₂ kinetics compared to that of central [cardiac output (Q̇), heart rate (HR)] and peripheral (deoxyhemoglobin over $\dot{\text{V}}$O₂ ratio ([HHb]/$\dot{\text{V}}$O₂)] O₂ delivery, during step-transitions to moderate-intensity exercise.

Methods

Thirty-six young healthy male participants (18 untrained; 18 trained) performed a ramp-incremental test to exhaustion and 3 step-transitions to moderate-intensity exercise. Q̇ and HR kinetics were measured in 18 participants (9 untrained; 9 trained).

Results

No significant correlation between τ̇$\dot{\text{V}}$O₂ and $\dot{\text{V}}$O_2max was found in trained participants (r = 0.29; p > 0.05) whereas a significant negative correlation was found in untrained (r = − 0.58; p < 0.05) and all participants (r = − 0.82; p < 0.05). τQ̇ (18.8 ± 5.5 s) and τHR (20.1 ± 6.2 s) were significantly greater than τ$\dot{\text{V}}$O₂ (13.9 ± 2.7 s) for trained (p < 0.05). No differences were found between τQ̇ (22.8 ± 8.45 s), τHR (21.2 ± 8.3 s) and τ$\dot{\text{V}}$O₂ (28.9 ± 5.7 s) for untrained (p > 0.05). τQ̇ demonstrated a significant strong positive correlation with τHR in trained (r = 0.76; p < 0.05) but not untrained (r = 0.61; p > 0.05). A significant overshoot in the [HHb]/$\dot{\text{V}}$O₂ ratio was found in the untrained groups (p < 0.05) but not in the trained groups (p > 0.05)

Conclusion

The results indicated that when comparing participants of different fitness status (i) there is a point at which greater V̇O_2max values are not accompanied by faster $\dot{\text{V}}$O₂ kinetics; (ii) central delivery of O₂ does not seem to limit the kinetics of $\dot{\text{V}}$O₂; and (iii) O₂ delivery within the active tissues might contribute to the slower $\dot{\text{V}}$O₂ kinetics response in untrained participants.

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Abbreviations

ATP:: Adenosine triphosphate
GET:: Gas-exchange threshold
[HHb]:: Deoxygenated hemoglobin
[HHb]/$\dot{\text{V}}$O₂ :: Deoxygenated hemoglobin over oxygen uptake ratio
HR:: Heart rate
NIRS:: Near-infrared spectroscopy
O₂ :: Oxygen
Q :: Cardiac output
PCr:: Phosphocreatine
τ :: Time-constant
T:: Trained
UT:: Untrained
V̇E:: Ventilation
$\dot{\text{V}}$CO₂ :: Carbon dioxide production
$\dot{\text{V}}$O₂ :: Oxygen uptake
$\dot{\text{V}}$O_2max :: Maximal oxygen uptake

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Acknowledgements

We would like to express our gratitude to the participants in this study.

Funding

Erin Calaine Inglis was supported by the Natural Sciences and Engineering Research Council (NSERC) Canada Graduate Scholarships-Doctoral (CGS D) Award. Dr. Juan M Murias was supported by the NSERC Discovery Grants Program (RGPIN-2016-03698) and by the Heart and Stroke Foundation of Canada National New Investigator Salary Award (#1047725).

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Authors and Affiliations

Faculty of Kinesiology, University of Calgary, KNB 434, 2500 University Drive NW, Calgary, AB, T2N 1N4, Canada
Erin Calaine Inglis, Danilo Iannetta & Juan M. Murias

Authors

Erin Calaine Inglis
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Danilo Iannetta
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Juan M. Murias
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Contributions

ECI, DI and JMM conceived and designed the research. ECI and DI performed the experiments. ECI and DI analyzed the results. ECI, DI, and JMM interpreted results of the experiment. ECI drafted the manuscript. ECI, DI, and JMM edited and revised the manuscript. ECI, DI, and JMM approved the final version of manuscript.

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Correspondence to Juan M. Murias.

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Communicated by Ellen adele dawson.

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Inglis, E.C., Iannetta, D. & Murias, J.M. Association between $\dot{\text{V}}$O₂ kinetics and $\dot{\text{V}}$O_2max in groups differing in fitness status. Eur J Appl Physiol 121, 1921–1931 (2021). https://doi.org/10.1007/s00421-021-04623-6

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Received: 06 October 2020
Accepted: 05 February 2021
Published: 17 March 2021
Issue Date: July 2021
DOI: https://doi.org/10.1007/s00421-021-04623-6

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Association between \(\dot{\text{V}}\)O₂ kinetics and \(\dot{\text{V}}\)O_2max in groups differing in fitness status