Abstract
Purpose
There is growing interest in the measurement of plasma levels of arginine vasopressin (AVP) for the assessment of mild dehydration. However, the principles of biological variation have not been applied to the study of AVP and understanding biological variation of AVP may provide insights regarding measurement thresholds. The purpose of this investigation was to determine the biological variation of AVP in healthy euhydrated individuals to understand the potential for establishing both static and/or change thresholds of importance.
Methods
We studied 29 healthy volunteers (24 men and 5 women) while controlling for hydration and pre-analytical factors. All subjects completed between 2–8 trials where biological variation was determined using widely published methods. We determined the intraindividual, interindividual, and analytical coefficients of variation (CVI, CVG, and CVA, respectively) and subsequently the index of individuality and heterogeneity (II and IH, respectively).
Results
AVP did not reach the IH threshold required to be considered useful in the dynamic assessment of physiological deviations from normal. AVP levels approached the II threshold required to be considered useful in the static assessment of physiological deviations from normal.
Conclusions
This analysis demonstrates that AVP assessment is unlikely to yield useful information about hydration status.
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Abbreviations
- AVP:
-
Arginine vasopressin
- CVA :
-
Analytic coefficient of variation
- CVG :
-
Interindividual coefficient of variation
- CVI :
-
Intraindividual coefficient of variation
- DL:
-
Decision level
- IH:
-
Index of heterogeneity
- II:
-
Index of individuality
- Posm:
-
Plasma osmolality
- SD:
-
Standard deviation
- Uosm:
-
Urine osmolality
- USG:
-
Urine specific gravity
- %CV:
-
Percent coefficient of variation
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This work was funded by the US Army Medical Research Materiel Command’s Military Operational Medicine Research Program.
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Authors KJS, RWK and SNC conceived and designed the research. JSS, RWK, and SNC conducted the study. KJS, JSS, and SNC analyzed the data. KJS, RWK, and SNC wrote the manuscript. All authors read, edited, and approved the manuscript.
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Sollanek, K.J., Staab, J.S., Kenefick, R.W. et al. Biological variation of arginine vasopressin. Eur J Appl Physiol 120, 635–642 (2020). https://doi.org/10.1007/s00421-020-04303-x
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DOI: https://doi.org/10.1007/s00421-020-04303-x