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1-Hydroxypyrene and oxidative stress marker levels among painting workers and office workers at shipyard

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Abstract

Objectives

The objective of this study was to assess the association between exposure to polycyclic aromatic hydrocarbons (PAHs) and oxidative stress among shipyard workers.

Methods

We recruited 82 painting workers in a shipyard and age/sex matched 137 office workers from the same shipyard company. Urine samples were used to assess for 1-hydroxypyrene (1-OHP) as an exposure biomarker for PAHs and to assess for 8-iso-prostaglandin F2α (iPF) as a biomarker for oxidative stress. Demographics, smoking, alcohol consumption, and working conditions information were obtained from a questionnaire survey.

Results

Geometric mean concentration (±standard deviation) of urinary 1-OHP among painting workers (587.9 ± 3.45 ng/g creatinine) was approximately 6.9 times higher than that among office workers (85.6 ± 2.09 ng/g creatinine; P value < 0.001). Compared to the office workers (163.5 ± 1.84 ng/g creatinine), the painting workers (190.6 ± 1.64 ng/g creatinine) had significantly higher urinary levels of iPF (P value = 0.044). Smokers had significantly higher urinary levels of iPF than nonsmokers in both painting workers (smokers 217.0 ± 1.63; nonsmokers 159.2 ± 1.52 ng/g creatinine; P value = 0.011) and office workers (smokers 181.3 ± 1.79; nonsmokers 138.4 ± 1.90 ng/g creatinine; P value = 0.015). Smokers among office workers had higher urinary levels of iPF than nonsmokers among painting workers, but difference was not significant.

Conclusion

Our results demonstrated that among shipyard workers, painting works were significantly associated with the exposure to PAHs, compared with the office works. However, iPF should be cautiously used to characterize the oxidative stress associated with the occupational PAHs exposure, because iPF is substantially affected by other factors such as smoking status.

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Acknowledgments

We thank the two anonymous reviewers for their valuable comments and suggestions to improve the quality of the paper.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Health, Environment and Safety, Eulji University, Seongnam, 461-713, Gyeonggi, Republic of Korea

    Younglim Kho

  2. Department of Visual Optics and Health Science, Graduate School of Health Science, Far East University, Eumsung, 369-700, Chungbuk, Republic of Korea

    Eun-Hee Lee

  3. Department of Occupational and Environmental Medicine, KS Hospital, 220 Wangbeodeul, Gwangsan, Gwangju, 506-304, Republic of Korea

    Hong Jae Chae

  4. Department of Environmental Health, Graduate School of Public Health, Seoul National University, Seoul, 151-742, Republic of Korea

    Kyungho Choi & Domyung Paek

  5. Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX, 77843, USA

    Sangshin Park

  6. Center for International Health Research, Rhode Island Hospital, The Warren Alpert Medical School of Brown University, Providence, RI, 02903, USA

    Sangshin Park

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  1. Younglim Kho
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  2. Eun-Hee Lee
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Correspondence to Sangshin Park.

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Kho, Y., Lee, EH., Chae, H.J. et al. 1-Hydroxypyrene and oxidative stress marker levels among painting workers and office workers at shipyard. Int Arch Occup Environ Health 88, 297–303 (2015). https://doi.org/10.1007/s00420-014-0955-4

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  • DOI: https://doi.org/10.1007/s00420-014-0955-4

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