Abstract
Purpose
To identify the types of viral infection in aqueous humor (AqH) among patients diagnosed as Fuchs uveitis syndrome (FUS) or Posner-Schlossman syndrome (PSS) and investigate their relevance to clinical manifestations and visual outcome.
Methods
A total of 375 patients and 171 patients were diagnosed as FUS or PSS in our department. AqH and serum samples from 68 FUS patients and 16 PSS patients were obtained during eye surgery. The viral etiologies, clinical features, auxiliary tests and visual prognosis of patients with FUS or PSS who underwent AqH analysis were analysed and compared.
Results
Among 68 FUS patients, rubella virus (RV), cytomegalovirus (CMV), herpes simplex virus (HSV) and varicella-zoster virus were identified in 17, 11, 1 and 1 patients, respectively. Seven patients with CMV and 1 with HSV were identified in 16 PSS patients. In both FUS and PSS groups, virus-associated eyes had higher proportion of secondary glaucoma and worse visual prognosis as compared with non-virus-associated eyes (all P < 0.05). In FUS group, specifically, CMV infection manifested as more obvious anterior segment inflammation and lower corneal endothelial cell density (CECD). RV infection showed a higher percentage of vitritis. In PSS group, CMV-associated PSS had a lower retinal nerve fiber layer thickness and CECD, worse visual prognosis as compared with non-virus-associated PSS (all P < 0.05).
Conclusion
Our study identified 4 types of viral infection in FUS and 2 types of viral infection in PSS. Virus-associated patients are usually associated with more obvious clinical signs and poor visual prognosis.
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Funding
This study was funded by the Key Project of Chongqing Science and Technology Bureau (CSTC2021jscx-gksb-N0010), Chongqing Outstanding Scientists Project (2019), Chongqing Chief Medical Scientist Project (2018) and Chongqing Science & Technology Platform and Base Construction Program (cstc2014pt-sy10002).
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of the First Affiliated Hospital of Chongqing Medical University and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Liu, H., Lai, Y., Liu, Y. et al. Clinical characteristics of viral-associated Fuchs uveitis syndrome and Posner-Schlossman syndrome in a Chinese population. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06502-0
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DOI: https://doi.org/10.1007/s00417-024-06502-0