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Peripheral and central retinal vascular changes in asymptomatic family members of patients with familial exudative vitreoretinopathy

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To evaluate the peripheral vascular changes and effects of these on macular microvasculature in asymptomatic family members of familial exudative vitreoretinopathy (FEVR) patients.

Methods

This is a retrospective study including 61 eyes of asymptomatic family members of FEVR patients. Retinal abnormalities were assessed via ultra-widefield fluorescein angiography (UWF-FA) and optical coherence tomography angiography (OCTA). The eyes were grouped into 3: the first group comprised of eyes with normal findings on UWF-FA; the second group comprised of eyes with abnormal findings on UWF-FA but without any retinal ischemia; and the third group involved eyes with retinal ischemia or neovascularization.

Results

Best corrected visual acuity (BCVA) was 20/20 in all eyes. Forty eyes (65.6%) had abnormalities on UWF-FA. The most common feature was peripheral vascular looping, increased tortuosity, and anastomosis (63.9%). ODM/ODD ratio was higher in group 3 compared to groups 1 and 2. Deep foveal VD was lower in group 1 compared to groups 2 and 3. The mean FAZ area and perimeter were smaller in groups 2 and 3 compared to group 1.

Conclusion

Even asymptomatic family members of FEVR patients may have significant peripheral retinal vascular abnormalities which may be associated with smaller optic disc, macular ectopia, and macular microvascular changes.

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Authors and Affiliations

  1. Department of Ophthalmology, Gazi University School of Medicine, Besevler, Ankara, 06500, Turkey

    Sengul Ozdek, Atike Burçin Tefon Aribas & Hatice Tuba Atalay

  2. Ankara Bilkent City Hospital, Ankara, 06800, Turkey

    Atike Burçin Tefon Aribas

Authors
  1. Sengul Ozdek
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  2. Atike Burçin Tefon Aribas
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  3. Hatice Tuba Atalay
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Contributions

All authors participated in the conception and design of the study. The preparation of the material, the selection of the images, and the data collection were also carried out by all authors. The first draft of the manuscript and the statistical analysis were done by Atike Burcin Tefon Aribas, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sengul Ozdek.

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Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Gazi University (Ethical approval number: E-91610558–604.01.02) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Consent to participate

Informed consent was obtained from all individual participants included in the study.

Conflict of interest

The authors declare no competing interests.

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This study has been presented in the AAO 2019 meeting as a poster and in the EVRS 2019 meeting as a paper presentation.

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Ozdek, S., Tefon Aribas, A.B. & Atalay, H.T. Peripheral and central retinal vascular changes in asymptomatic family members of patients with familial exudative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol 261, 3449–3456 (2023). https://doi.org/10.1007/s00417-023-06184-0

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  • DOI: https://doi.org/10.1007/s00417-023-06184-0

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