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The effect of sodium hyaluronate on tear film stability in patients with dry eye syndrome after cataract surgery

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Abstract

Background

This study aimed to observe the changes in the ocular surface after phacoemulsification in patients with age-related cataracts with respect to the addition of varying concentrations of hyaluronate.

Methods

Patients with dry eye syndrome were treated with 0.3% and 0.1% sodium hyaluronate eye drops to evaluate the clinical improvement in each treatment group. A total of 73 patients (91 eyes) with age-related cataracts suffering from dry eye syndrome after phacoemulsification were divided into treatment group A (30 eyes), undergoing conventional therapy and treatment with 0.3% sodium hyaluronate; treatment group B (31 eyes), undergoing conventional therapy and treatment with 0.1% sodium hyaluronate; and the control group (group C; 30 eyes), undergoing conventional therapy only. Two groups were given different concentrations of sodium hyaluronate eye drops four times a day (should be completed between 8 AM and 8 PM), one drop at a time.

Results

Seven days, 2 weeks, 1 month, and 2 months postoperatively, there were significant differences in the Schirmer I test (SIt), first noninvasive tear film break-up time (NIBUTf), average noninvasive tear film break-up time (NIBUTav), tear meniscus height (TMH), and irregularity (when the refractive force of different parts of different meridians on the same meridian is different. The main manifestation is that the two meridians on the anterior surface of the cornea do not show a 90-degree vertical distribution, which cannot be corrected by conventional astigmatism lenses) between the three groups (p < 0.05). When compared with group C, there were significant differences in the SIt, NIBUTf, NIBUTav, TMH, and irregularity of group A and group B (p < 0.05). When compared with group B, there were significant improvements in the SIt, NIBUTf, NIBUTav, and TMH in group A (p < 0.05).

Conclusions

In the early stage after phacoemulsification, the stability of the tear film is reduced. Adding sodium hyaluronate eye drops can restore tear film structure and improve corneal surface regularity, and a 0.3% solution of sodium hyaluronate eye drops is more effective than a 0.1% solution.

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Funding

This study was funded by the National Natural Science Foundation of China Science Foundation for Youth (No. 81100700). The funding body had no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Key Laboratory of Ophthalmology, The Fourth Affiliated Hospital of China Medical University, Ophthalmological Center of China Medical University, China Medical University, No. 102 of Nanqi Street, Heping District, Shenyang, 110005, Liaoning, China

    Nan Chen, Jin-Song Zhang, Tian-Xiao Zhang, Bao-Liang Fan & Yuan Ning

Authors
  1. Nan Chen
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  2. Jin-Song Zhang
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  3. Tian-Xiao Zhang
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  4. Bao-Liang Fan
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  5. Yuan Ning
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Corresponding author

Correspondence to Yuan Ning.

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Research involving human participants

The study was approved by the ethics committee of the Fourth Affiliated Hospital of China Medical University.

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All patients signed an informed consent form.

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The authors declare no competing interests.

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Chen, N., Zhang, JS., Zhang, TX. et al. The effect of sodium hyaluronate on tear film stability in patients with dry eye syndrome after cataract surgery. Graefes Arch Clin Exp Ophthalmol 261, 1011–1017 (2023). https://doi.org/10.1007/s00417-022-05880-7

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  • DOI: https://doi.org/10.1007/s00417-022-05880-7

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