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En face optical coherence tomography transillumination for evaluation of retinal pigment epithelium alteration in central serous chorioretinopathy: correlation with multimodal imaging

  • Retinal Disorders
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Abstract   

Purpose

To study optical coherence tomography (OCT) en face imaging approach to evaluate retinal pigment epithelium (RPE) alteration in central serous chorioretinopathy (CSC).

Methods

Forty eyes with CSC were imaged with structural en face OCT, fluorescein angiography (FA), and fundus autofluorescence (FAF). Structural en face OCT projections were generated using a 200-µm slab with the inner limit at the outer choroid to register choroidal hypertransmission signal in transillumination manner. Two masked graders independently defined the area of RPE alteration on resultant images. Agreement between graders and correlation between imaging modalities was assessed by kappa coefficients (k) and intraclass correlation coefficients (ICC), respectively.

Results

The measurements derived from three methods were highly correlated with ICC of 0.99 (95% CI 0.99 to 1.0) for OCT and FA, 0.97 (95% CI 0.93 to 0.99) for OCT and FAF, and 0.98 (95% CI 0.95 to 0.99) for FA and FAF. For the measurement of the area of RPE alteration, kappa value for inter-grader agreement was 0.94 for OCT, 0.89 for FA, and 0.92 for FAF.

Conclusion

En face OCT proved a reliable tool for the noninvasive evaluation of RPE status in CSC.

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References

  1. Yehoshua Z, Garcia Filho CAA, Penha FM et al (2013) Comparison of geographic atrophy measurements from the OCT fundus image and the sub-RPE slab image. Ophthalmic Surg Lasers Imaging Retina 44:127–132

    Article  Google Scholar 

  2. Chhablani J, Cohen FB, Central Serous Chorioretinopathy International Group (2020) Multimodal imaging-based central serous chorioretinopathy classification. Ophthalmol Retina 4:1043–1046

    Article  Google Scholar 

  3. Maltsev DS, Kulikov AN, Burnasheva MA, Kazak AA, Chhablani J (2021) Retinal pigment epithelium reflectivity at leakage site on spectral-domain optical coherence tomography in acute central serous chorioretinopathy. Semin Ophthalmol 36:354–359

    Article  Google Scholar 

  4. Nicholson B, Noble J, Forooghian F, Meyerle C (2013) Central serous chorioretinopathy: update on pathophysiology and treatment. Surv Ophthalmol 58:103–126

    Article  Google Scholar 

  5. Gupta V, Gupta P, Dogra MR, Gupta A (2010) Spontaneous closure of retinal pigment epithelium microrip in the natural course of central serous chorioretinopathy. Eye (Lond) 24:595–599

    Article  CAS  Google Scholar 

  6. Schaal KB, Rosenfeld PJ, Gregori G, Yehoshua Z, Feuer WJ (2016) Anatomic clinical trial endpoints for nonexudative age-related macular degeneration. Ophthalmology 123:1060–1079

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Ophthalmology, Military Medical Academy, 21, Botkinskaya Str, 194044, St. Petersburg, Russia

    Maltsev D.S., Kulikov A.N. & Burnasheva M.A.

  2. University of Pittsburgh, UPMC Eye Center, 203 Lothrop Street, Pittsburgh, PA, 15213, USA

    Chhablani J.

Authors
  1. Maltsev D.S.
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  2. Kulikov A.N.
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  3. Burnasheva M.A.
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  4. Chhablani J.
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Corresponding author

Correspondence to Maltsev D.S..

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Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Independent Ethics Committee of Military Medical Academy and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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The authors declare no competing interests.

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D.S., M., A.N., K., M.A., B. et al. En face optical coherence tomography transillumination for evaluation of retinal pigment epithelium alteration in central serous chorioretinopathy: correlation with multimodal imaging. Graefes Arch Clin Exp Ophthalmol 260, 2231–2237 (2022). https://doi.org/10.1007/s00417-021-05537-x

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  • DOI: https://doi.org/10.1007/s00417-021-05537-x

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