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Long-term results of choroidal neovascularization secondary to angioid streaks

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To investigate factors contributing to the visual prognosis of choroidal neovascularization (CNV) secondary to angioid streaks (AS) in a long-term follow-up (> 5 years) study.

Methods

Twenty-one patients (32 eyes) affected by CNV secondary to AS were enrolled retrospectively and divided into three groups according to the period of CNV recurrence from the final treatment: group A, no recurrence for more than 12 months; group B, no recurrence for 6–12 months; and group C, no recurrence for < 6 months or ongoing. According to the above classification, we assessed best-corrected visual acuity (BCVA), peau d’orange area, the number of photodynamic treatments and/or intravitreal antiangiogenic drug injections, central choroidal thickness (CCT) and central retinal thickness (CRT) using optical coherence tomography, and enlargement of retinal pigment epithelium (RPE) atrophy.

Results

The median follow-up time was 91 months. The median logarithm of the minimum angle of resolution BCVA significantly deteriorated from 0 at baseline to 1 at final follow-up (p < 0.05). Especially, final BCVA in group A showed worst visual outcome despite lowest number of treatments. Peau d’orange areas at baseline were found in 32 eyes (100%). There were no significant differences between initial CRT and final CRT. Median CCT was significantly reduced from 188 μm at baseline to 96 μm at final follow-up (p < 0.05). The median number of treatments was 3.5. Enlargement of RPE atrophy at baseline was found in 31 eyes (96.8%).

Conclusions

Despite the regression of CNV secondary to AS following treatment, the visual prognosis was poor due to the presence of peau d’orange areas, choroidal thinning, and increased RPE atrophy.

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Abbreviations

CNV:

choroidal neovascularization

AS:

angioid streaks

BCVA:

best-corrected visual acuity

CCT:

central choroidal thickness

CRT:

central retinal thickness

RPE:

retinal pigment epithelium

TTT:

transpupillary thermotherapy

PDT:

photodynamic therapy

VEGF:

vascular endothelial growth factor

AMD:

age-related macular disease

CFP:

color fundus photography

FA:

fluorescein angiography

IA:

indocyanine green angiography

FAF:

fundus auto-fluorescence

SD-OCT:

spectral-domain optical coherence tomography

NIR:

near infrared reflectance

logMAR:

logarithm of the minimum angle of resolution

EDI:

enhanced depth imaging

PRN:

pro re nata

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Authors and Affiliations

  1. Department of Ophthalmology, Kansai Medical University, 5-1, Shinmachi 2-chome, Hirakata, Osaka, Japan

    Hidetsugu Mori, Haruhiko Yamada & Kanji Takahashi

Authors
  1. Hidetsugu Mori
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  2. Haruhiko Yamada
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  3. Kanji Takahashi
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Contributions

Research design was performed by Hidetsugu Mori and Kanji Takahashi.

Data analysis was performed by Hidetsugu Mori.

Hidetsugu Mori wrote the paper with support of Haruhiko Yamada and Kanji Takahashi.

Corresponding author

Correspondence to Hidetsugu Mori.

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The authors declare that they have no conflict of interest.

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The research was conducted in accordance with the guiding principles of the Declaration of Helsinki and approved by the institutional review board of Kansai Medical University.

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Mori, H., Yamada, H. & Takahashi, K. Long-term results of choroidal neovascularization secondary to angioid streaks. Graefes Arch Clin Exp Ophthalmol 258, 1863–1869 (2020). https://doi.org/10.1007/s00417-020-04760-2

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  • DOI: https://doi.org/10.1007/s00417-020-04760-2

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