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Baseline clinical features predict visual outcome in young patients with central retinal vein occlusion

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate prognostic factors in young patients with central retinal vein occlusion (CRVO).

Methods

Retrospective case series. CRVO patients aged ≤ 50 and follow-up ≥ 6 months were enrolled. The best corrected visual acuity (BCVA) and central retinal thickness (CRT) at baseline, 3 months, 6 months, and last visit were documented. Severity of retinopathy was graded by comparing to standard photos. Prognostic factors associated with visual outcome at 6 months were evaluated by multiple linear regression models.

Results

A total of 73 eyes from 69 patients with mean age 37.6 ± 8.5 were enrolled. Forty-seven (68%) patients were male. The mean follow-up duration was 25.9 ± 23.0 months. LogMAR BCVA improved from 0.979 ± 0.785 at baseline to 0.594 ± 0.748 at the 6 months (p < 0.001) and CRT improved from 475 ± 222 μm to 299 ± 104 μm (p < 0.001). Forty-eight (66%) eyes required anti-vascular endothelial growth factor (anti-VEGF) treatment. The mean number of injections was 2.25 ± 1.41 in the first 6 months and 75% of eyes received ≦ 3 injections during the clinical course. The baseline BCVA (coefficient 0.518, p < 0.001), grade of retinal hemorrhage (coefficient 0.230, p = 0.006), grade of retinal venous engorgement (coefficient 0.238, p = 0.011), grade of optic disc edema (coefficient − 0.226, p = 0.005), and diabetes mellitus (coefficient 0.264, p = 0.047) were the independent factors associated with visual outcome at 6 months.

Conclusions

Baseline clinical features are useful for the prediction of visual outcome at 6 months in young CRVO patients.

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Availability of data and material

The datasets generated during and/or analyzed during the current study are not publicly available due to the involvement of human participants and the regulation of Chang Gung Memorial Hospital Institutional Review Board, but are available from the corresponding author on reasonable request.

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Authors and Affiliations

  1. Department of Ophthalmology, Keelung Chang Gung Memorial Hospital, No. 222, Maijin Road, Keelung City, 204, Taiwan

    Yeo-Yang Koh, Jerry Chien-Chieh Huang & Ling Yeung

  2. College of Medicine, Chang Gung University, Taoyuan, Taiwan

    Chi-Chun Lai, Wei-Chi Wu, Yih-Shiou Hwang, Kuan-Jen Chen, Nan-Kai Wang, Tun-Lu Chen, Laura Liu & Ling Yeung

  3. Department of Ophthalmology, Chang Gung Memorial Hospital, Taoyuan, Taiwan

    Chi-Chun Lai, Wei-Chi Wu, Yih-Shiou Hwang, Kuan-Jen Chen, Nan-Kai Wang, Tun-Lu Chen, Jerry Chien-Chieh Huang & Laura Liu

  4. Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University, New York, NY, USA

    Nan-Kai Wang

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  1. Yeo-Yang Koh
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Chi-Chun Lai, Wei-Chi Wu, Yih-Shiou Hwang, Kuan-Jen Chen, Nan-Kai Wang, Tun-Lu Chen, Jerry Chien-Chieh Huang, Laura Liu, and Ling Yeung. The first draft of the manuscript was written by Yeo-Yang Koh and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Ling Yeung.

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The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Chang Gung Memorial Hospital Institutional Review Board (IRB No.: 201600907B0) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was waived by the Chang Gung Memorial Hospital Institutional Review Board (IRB No.: 201600907B0).

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Informed consent was waived by the Chang Gung Memorial Hospital Institutional Review Board (IRB No.: 201600907B0).

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Koh, YY., Lai, CC., Wu, WC. et al. Baseline clinical features predict visual outcome in young patients with central retinal vein occlusion. Graefes Arch Clin Exp Ophthalmol 258, 1367–1377 (2020). https://doi.org/10.1007/s00417-020-04679-8

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  • DOI: https://doi.org/10.1007/s00417-020-04679-8

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