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Preoperative aniseikonia is a prognostic factor for postoperative stereopsis in patients with unilateral epiretinal membrane

  • Retinal Disorders
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Abstract

Purpose

To investigate stereopsis and other visual functions in patients with unilateral epiretinal membrane (ERM) and to identify vision-related parameters affecting stereopsis.

Methods

This prospective study included 63 consecutive patients who were scheduled to undergo vitrectomy for unilateral idiopathic ERM. We examined stereopsis (Titmus Stereo Test, TST; TNO stereotest, TNO), best-corrected visual acuity (BCVA), letter contrast sensitivity, severity of metamorphopsia, and degree of aniseikonia preoperatively and 6 months postoperatively.

Results

Preoperatively, we observed significant correlation between TST scores and other vision-related parameters except severity of metamorphopsia and between TNO score and all the vision-related parameters. Multiple regression analysis showed that preoperative TST and TNO scores were significantly associated with the degree of aniseikonia (both P < 0.01). ERM surgery significantly improved stereopsis, BCVA, contrast sensitivity, and metamorphopsia, but not aniseikonia. Postoperatively, TST was significantly associated with BCVA, and TNO showed association with BCVA and aniseikonia. Postoperative TST and TNO scores showed significant correlation with preoperative aniseikonia (P < 0.005 and P < 0.001, respectively).

Conclusions

Impairment of stereopsis in patients with unilateral ERM was considered to be due to retinally induced aniseikonia. Aniseikonia did not improve by surgery, and preoperative aniseikonia can be a prognostic factor for postoperative stereopsis.

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References

  1. Wheatstone C (1838) Contributions to the physiology of vision.—part the first. On some remarkable and hitherto unobserved phenomena of binocular vision. Philos Trans R Soc Lond Ser B Biol Sci 128:371–394

    Google Scholar 

  2. Lam AK, Chau AS, Lam WY et al (1996) Effect of naturally occurring visual acuity differences between two eyes in stereoacuity. Ophthalmic Physiol Opt 16:189–195

    CAS  PubMed  Google Scholar 

  3. Donzis PB, Rappazzo JA, Burde RM, Gordon M (1983) Effect of binocular variations of Snellen's visual acuity on Titmus stereoacuity. Arch Ophthalmol 101:930–932

    CAS  PubMed  Google Scholar 

  4. Larson WL, Bolduc M (1991) Effect of induced blur on visual acuity and stereoacuity. Optom Vis Sci 68:294–298

    CAS  PubMed  Google Scholar 

  5. Levy NS, Glick EB (1974) Stereoscopic perception and Snellen visual acuity. Am J Ophthalmol 78:722–724

    CAS  PubMed  Google Scholar 

  6. Goodwin RT, Romano PE (1985) Stereoacuity degradation by experimental and real monocular and binocular amblyopia. Invest Ophthalmol Vis Sci 26:917–923

    CAS  PubMed  Google Scholar 

  7. Erickson P, McGill EC (1992) Role of visual acuity, stereoacuity, and ocular dominance in monovision patient success. Optom Vis Sci 69:761–764

    CAS  PubMed  Google Scholar 

  8. Katsumi O, Tanino T, Hirose T (1986) Effect of aniseikonia on binocular function. Invest Ophthalmol Vis Sci 27:601–604

    CAS  PubMed  Google Scholar 

  9. Lovasik JV, Szymkiw M (1985) Effects of aniseikonia, anisometropia, accommodation, retinal illuminance, and pupil size on stereopsis. Invest Ophthalmol Vis Sci 26:741–750

    CAS  PubMed  Google Scholar 

  10. Pierce DM (1975) Comparability of two methods of estimating real-depth acuity. Ophthalmologica 171:224–235

    CAS  PubMed  Google Scholar 

  11. Weinman J, Cooke V (1982) Eye dominance and stereopsis. Perception 11:207–210

    CAS  PubMed  Google Scholar 

  12. Kani W (1978) Stereopsis and spatial perception in amblyopes and uncorrected ametropes. Br J Ophthalmol 62:756–762

    CAS  PubMed  PubMed Central  Google Scholar 

  13. Watanabe A, Arimoto S, Nishi O (2009) Correlation between metamorphopsia and epiretinal membrane optical coherence tomography findings. Ophthalmology 116:1788–1793

    PubMed  Google Scholar 

  14. Bae SH, Kim D, Park TK et al (2013) Preferential hyperacuity perimeter and prognostic factors for metamorphopsia after idiopathic epiretinal membrane surgery. Am J Ophthalmol 155:109–117

    PubMed  Google Scholar 

  15. Okamoto F, Sugiura Y, Okamoto Y et al (2012) Associations between metamorphopsia and foveal microstructure in patients with epiretinal membrane. Invest Ophthalmol Vis Sci 53:6770–6775

    PubMed  Google Scholar 

  16. Kinoshita T, Imaizumi H, Okushiba U et al (2012) Time course of changes in metamorphopsia, visual acuity, and OCT parameters after successful epiretinal membrane surgery. Invest Ophthalmol Vis Sci 53:3592–3597

    PubMed  Google Scholar 

  17. Ooto S, Hangai M, Takayama K et al (2011) High-resolution imaging of the photoreceptor layer in epiretinal membrane using adaptive optics scanning laser ophthalmoscopy. Ophthalmology 2011(118):873–881

    Google Scholar 

  18. Matsumoto C, Arimura E, Okuyama S et al (2003) Quantification of metamorphopsia in patients with epiretinal membranes. Invest Ophthalmol Vis Sci 44:4012–4016

    PubMed  Google Scholar 

  19. Arimura E, Matsumoto C, Okuyama S et al (2005) Retinal contraction and metamorphopsia scores in eyes with idiopathic epiretinal membrane. Invest Ophthalmol Vis Sci 46:2961–2966

    PubMed  Google Scholar 

  20. Okamoto F, Sugiura Y, Okamoto Y et al (2014) Time course of changes in aniseikonia and foveal microstructure after vitrectomy for epiretinal membrane. Ophthalmology 121:2255–2260

    PubMed  Google Scholar 

  21. Okamoto F, Sugiura Y, Okamoto Y et al (2017) Aniseikonia in various retinal disorders. Graefes Arch Clin Exp Ophthalmol 255:1063–1071

    PubMed  Google Scholar 

  22. Moon BG, Yang YS, Chung H, Sohn J (2019) Correlation between macular microstructures and aniseikonia after idiopathic epiretinal membrane removal. Retina. https://doi.org/10.1097/IAE.0000000000002530 [Epub ahead of print]

  23. Tanikawa A, Shimada Y, Horiguchi M (2018) Comparison of visual acuity, metamorphopsia, and aniseikonia in patients with an idiopathic epiretinal membrane. Jpn J Ophthalmol 62:280–285

    CAS  PubMed  Google Scholar 

  24. Hirata A, Nakada H, Mine K et al (2019) Relationship between the morphology of the foveal avascular zone and the degree of aniseikonia before and after vitrectomy in patients with unilateral epiretinal membrane. Graefes Arch Clin Exp Ophthalmol 257:507–515

    Google Scholar 

  25. Ichikawa Y, Imamura Y, Ishida M (2018) Associations of aniseikonia with metamorphopsia and retinal displacements after epiretinal membrane surgery. Eye (Lond) 32:400–405

    CAS  Google Scholar 

  26. Takabatake M, Higashide T, Udagawa S, Sugiyama K (2018) Postoperative changes and prognostic factors of visual acuity, metamorphopsia, and aniseikonia after vitrectomy for epiretinal membrane. Retina 38:2118–2127

    PubMed  Google Scholar 

  27. Sugiura Y, Okamoto F, Okamoto Y et al (2014) Contrast sensitivity and foveal microstructure following vitrectomy for epiretinal membrane. Invest Ophthalmol Vis Sci 55:7594–7600

    PubMed  Google Scholar 

  28. Bouwens MD, Meurs JC (2003) Sine Amsler Charts: a new method for the follow-up of metamorphopsia in patients undergoing macular pucker surgery. Graefes Arch Clin Exp Ophthalmol 241:89–93

    PubMed  Google Scholar 

  29. Wong JG, Sachdev N, Beaumont PE, Chang AA (2005) Visual outcomes following vitrectomy and peeling of epiretinal membrane. Clin Exp Ophthalmol 33:373–378

    PubMed  Google Scholar 

  30. Asaria R, Garnham L, Gregor ZJ, Sloper JJ (2008) A prospective study of binocular visual function before and after successful surgery to remove a unilateral epiretinal membrane. Ophthalmology 115:1930–1937

    PubMed  Google Scholar 

  31. Okamoto F, Sugiura Y, Okamoto Y et al (2015) Stereopsis and optical coherence tomography findings after epiretinal membrane surgery. Retina 35:1415–1421

    PubMed  Google Scholar 

  32. Hikichi T, Onodera A, Ishiko S et al (2001) Stereo acuity in patients with unilateral macular hole and after unilateral macular hole surgery. Graefes Arch Clin Exp Ophthalmol 239:128–132

    CAS  PubMed  Google Scholar 

  33. Mireskandari K, Garnham L, Sheard R et al (2004) A prospective study of the effect of a unilateral macular hole on sensory and motor binocular function and recovery following successful surgery. Br J Ophthalmol 88:1320–1324

    CAS  PubMed  PubMed Central  Google Scholar 

  34. Watanabe H, Okamoto F, Sugiura Y et al (2014) Stereopsis after successful surgery for rhegmatogenous retinal detachment. Graefes Arch Clin Exp Ophthalmol 252:1207–1212

    PubMed  Google Scholar 

  35. Chylack LT Jr, Wolfe JK, Singer DM et al (1993) The Lens opacities classification system III. The longitudinal study of cataract study group. Arch Ophthalmol 111:831–836

    PubMed  Google Scholar 

  36. Katsumi O, Miyanaga Y, Hirose T et al (1988) Binocular function in unilateral aphakia. Correlation with aniseikonia and stereoacuity. Ophthalmology 95:1088–1093

    CAS  PubMed  Google Scholar 

  37. Shimada H, Nakashizuka H, Hattori T et al (2009) Double staining with brilliant blue G and double peeling for epiretinal membranes. Ophthalmology 116:1370–1376

    PubMed  Google Scholar 

  38. Okamoto F, Sugiura Y, Moriya Y et al (2016) Aniseikonia and foveal microstructure in patients with idiopathic macular hole. Ophthalmology 123:1926–1932

    PubMed  Google Scholar 

  39. Benegas NM, Egbert J, Engel WK, Kushner BJ (1999) Diplopia secondary to aniseikonia associated with macular disease. Arch Ophthalmol 117:896–899

    CAS  PubMed  Google Scholar 

  40. Brooks SE, Johnson D, Fischer N (1996) Anisometropia and binocularity. Ophthalmology 103:1139–1143

    CAS  PubMed  Google Scholar 

  41. de Wit GC (2008) Clinical usefulness of the aniseikonia inspector: a review. Binocul Vis Strabismus Q 23:207–214

    PubMed  Google Scholar 

  42. de Wit GC, Muraki CS (2006) Field-dependent aniseikonia associated with an epiretinal membrane a case study. Ophthalmology 113:58–62

    PubMed  Google Scholar 

  43. Ugarte M, Williamson TH (2005) Aniseikonia associated with epiretinal membranes. Br J Ophthalmol 89:1576–1580

    CAS  PubMed  PubMed Central  Google Scholar 

  44. Berens C, Bannon RE (1963) Aniseikonia: a present appraisal and some practical considerations. Arch Ophthalmol 70:181–188

    CAS  PubMed  Google Scholar 

  45. Kramer PW, Lubkin V, Pavlica M, Covin R (1999) Symptomatic aniseikonia in unilateral and bilateral pseudophakia. A projection space eikonometer study. Binocul Vis Strabismus Q 14:183–190

    CAS  PubMed  Google Scholar 

  46. Pesin SR, Olk RJ, Grand MG et al (1991) Vitrectomy for premacular fibroplasia: prognostic factors, long-term follow-up, and time course of visual improvement. Ophthalmology 98:1109–1114

    CAS  PubMed  Google Scholar 

  47. Sjöstrand J, Anderson C (1986) Micropsia and metamorphopsia in the re-attached macula following retinal detachment. Acta Ophthalmol 64:425–432

    Google Scholar 

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Authors and Affiliations

  1. Department of Ophthalmology, Faculty of Medicine, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki, 305-8575, Japan

    Fumiki Okamoto, Shohei Morikawa, Yoshimi Sugiura, Sujin Hoshi, Takahiro Hiraoka & Tetsuro Oshika

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  1. Fumiki Okamoto
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  2. Shohei Morikawa
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  3. Yoshimi Sugiura
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  4. Sujin Hoshi
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  5. Takahiro Hiraoka
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  6. Tetsuro Oshika
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Correspondence to Fumiki Okamoto.

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The authors declare that they have no conflicts of interest.

Ethical approval

We conducted this prospective comparative study in accordance with the Declaration of Helsinki and received approval from the institutional review committees of the University of Tsukuba Hospital. Prior to enrollment in the study, all patients provided informed consent after the nature of the study was explained (On line 69–72 of the manuscript).

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Okamoto, F., Morikawa, S., Sugiura, Y. et al. Preoperative aniseikonia is a prognostic factor for postoperative stereopsis in patients with unilateral epiretinal membrane. Graefes Arch Clin Exp Ophthalmol 258, 743–749 (2020). https://doi.org/10.1007/s00417-020-04625-8

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  • DOI: https://doi.org/10.1007/s00417-020-04625-8

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