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Antiplatelet and anticoagulant agents in vitreoretinal surgery: a prospective multicenter study involving 804 patients

  • Retinal Disorders
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Abstract

Purpose

To assess the rate of hemorrhagic complications after vitreoretinal surgery and the influence of antithrombotic agents.

Methods

Hemorrhagic complications of vitreoretinal procedures performed in seven ophthalmologic centers on patients treated or not treated with antiplatelet (AP) or anticoagulant (AC) agents were prospectively collected. Patients’ characteristics, surgical techniques, and complications were recorded during surgery and for 1 month after.

Results

Eight hundred four procedures were performed between January 2015 and April 2015. Among them, 18.4% were treated with AP agents (n = 148) and 7.8% with AC agents (n = 63), with 18 of them treated with NOACS (new oral anticoagulants). AP or AC agents were continued in 96.5% and 80.7% of cases, respectively. Fifty-three patients (6.6%) developed one or more hemorrhagic complications in one eye during this period. In univariate analysis, AC agents were not associated with hemorrhagic complications (P = 0.329) in contrast to AP (P = 0.005). However, in multivariate analysis, AP agents were no longer associated with hemorrhagic complications and the intraoperative use of endodiathermy was the only factor associated with hemorrhagic complications (P = 0.001).

Conclusions

This study showed that AP and AC agents were not a factor associated with hemorrhagic complications during vitreoretinal surgery. The continuation of these treatments should be considered without risk of severe hemorrhagic complications.

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Acknowledgements

Surgeon members of the Club Francophone des Spécialistes de la Rétine (CFSR).

Philippe Koehrer, Firras Youssef, Yann Kauffmann (University Hospital, Dijon, France).

Vincent Soler (University Hospital, Toulouse, France).

Anne Robinet (OPHTASIAM, Brest, France).

Frederic Matonti (University Hospital, Marseille, France).

Vincent Gualino (Clinique Honoré Cave, Montauban, France).

Joel Uzzan (Clinique Mathilde, Rouen, France).

Agnes Glacet Bernard (Centre Hospitalier Intercommunal, Créteil, France).

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University Hospital, 14 rue Paul Gaffarel, 21079, Dijon, France

    Cyril Meillon, Pierre Henry Gabrielle, Alain M. Bron & Catherine Creuzot-Garcher

  2. Plurithematic Clinical Investigation Center (CIC-P) INSERM 803 and Department of Medical Pharmacology, University Hospital, Dijon, France

    Maxime Luu

  3. Hospital Hygiene and Epidemiology Unit, University Hospital, Dijon, France

    Ludwig S. Aho-Glele

  4. Eye and Nutrition Research Group, CSGA, UMR 1324 INRA, 6265 CNRS, University of Burgundy, Dijon, France

    Alain M. Bron & Catherine Creuzot-Garcher

Authors
  1. Cyril Meillon
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  2. Pierre Henry Gabrielle
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  3. Maxime Luu
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  4. Ludwig S. Aho-Glele
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for the CFSR research net

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Correspondence to Alain M. Bron.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (place name of institute/committee) and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Meillon, C., Gabrielle, P.H., Luu, M. et al. Antiplatelet and anticoagulant agents in vitreoretinal surgery: a prospective multicenter study involving 804 patients. Graefes Arch Clin Exp Ophthalmol 256, 461–467 (2018). https://doi.org/10.1007/s00417-017-3897-1

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  • DOI: https://doi.org/10.1007/s00417-017-3897-1

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