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Pattern and causes of visual loss in Behçet’s uveitis: short-term and long-term outcomes

  • Inflammatory Disorders
  • Published:
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Abstract

Background

To analyze the pattern and causes of visual loss in patients with Behçet’s uveitis and to report on the short-term outcome at 6 months and at last follow-up visit. Also, to analyze the pattern of visual acuity changes in eyes with and without macular involvement at the specified time points.

Methods

This is a retrospective cohort study of a single-center in an academic practice. Fifty-three patients with Behçet’s uveitis evaluated between 2004 and 2014 were included. Data on patients diagnosed with Behçet’s uveitis were entered retrospectively into a database and analyzed.

Results

Included were 93 eyes with Behçet’s uveitis involving the posterior segment. Frequencies of ≤20/50 and of ≤20/200 VA at presentation were 23.7% and 37.6%, respectively. Retinitis, macular inflammatory infiltrate, and dense vitritis were significantly associated with worse vision. Eyes with macular atrophy and macular inflammatory infiltrate sustained the worst logMAR VA at presentation (1.87 and 1.73, respectively) compared to eyes with cystoid macular edema and epiretinal membrane (0.76 and 0.63, respectively). Eyes with no macular involvement had the best VA at presentation. Mean difference in logMAR VA between presentation and the specified time points was greatest for eyes with macular inflammatory infiltrate.

Conclusions

Behçet’s disease affected mostly young males with a male-to-female ratio of 4.8:1. Panuveitis and posterior uveitis were the predominant forms and they were intrinsically associated with sight-threatening potential and breadth of ocular complications for which aggressive immunosuppressive therapy was essential.

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Authors and Affiliations

  1. Department of Ophthalmology, Hadassah Medical Center, Jerusalem, Israel

    Radgonde Amer, Walaa Alsughayyar & Diego Almeida

Authors
  1. Radgonde Amer
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  2. Walaa Alsughayyar
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  3. Diego Almeida
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Corresponding author

Correspondence to Radgonde Amer.

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No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

For this type of study (retrospective study) formal consent is not required.

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Amer, R., Alsughayyar, W. & Almeida, D. Pattern and causes of visual loss in Behçet’s uveitis: short-term and long-term outcomes. Graefes Arch Clin Exp Ophthalmol 255, 1423–1432 (2017). https://doi.org/10.1007/s00417-017-3667-0

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  • DOI: https://doi.org/10.1007/s00417-017-3667-0

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